New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

David J. Polman; Douglas K. Price; William D. Figg

doi:10.1080/15384047.2015.1108498

New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

David J. Polman, Douglas K. Price, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.

Original language	English
Pages (from-to)	1702-1703
Number of pages	2
Journal	Cancer Biology and Therapy
Volume	16
Issue number	12
DOIs	https://doi.org/10.1080/15384047.2015.1108498
State	Published - 2 Dec 2015
Externally published	Yes

Keywords

NF-κB pathway
PIK3/Akt pathway
PSGR
PTEN
bigenic mouse model
disease progression
genetic synergism
prostate cancer

Access to Document

10.1080/15384047.2015.1108498

Cite this

@article{67247aedc03342f9b523186d24a79798,

title = "New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer",

abstract = "A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.",

keywords = "NF-κB pathway, PIK3/Akt pathway, PSGR, PTEN, bigenic mouse model, disease progression, genetic synergism, prostate cancer",

author = "Polman, {David J.} and Price, {Douglas K.} and Figg, {William D.}",

note = "Publisher Copyright: {\textcopyright} 2015 Taylor & Francis Group, LLC.",

year = "2015",

month = dec,

day = "2",

doi = "10.1080/15384047.2015.1108498",

language = "English",

volume = "16",

pages = "1702--1703",

journal = "Cancer Biology and Therapy",

issn = "1538-4047",

publisher = "Taylor and Francis Ltd.",

number = "12",

}

TY - JOUR

T1 - New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

AU - Polman, David J.

AU - Price, Douglas K.

AU - Figg, William D.

PY - 2015/12/2

Y1 - 2015/12/2

N2 - A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.

AB - A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.

KW - NF-κB pathway

KW - PIK3/Akt pathway

KW - PSGR

KW - PTEN

KW - bigenic mouse model

KW - disease progression

KW - genetic synergism

KW - prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=84954517647&partnerID=8YFLogxK

U2 - 10.1080/15384047.2015.1108498

DO - 10.1080/15384047.2015.1108498

M3 - Article

AN - SCOPUS:84954517647

SN - 1538-4047

VL - 16

SP - 1702

EP - 1703

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 12

ER -

New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

Abstract

Keywords

Access to Document

Fingerprint

Cite this