New directions for induction immunosuppression strategy in solid organ transplantation

Jason S. Hawksworth, David Leeser, Rahul M. Jindal, Edward Falta, Douglas Tadaki, Eric A. Elster*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Background: Solid organ transplant centers are increasingly using induction immunosuppression strategies. Induction immunosuppression involves the use of intense therapy at the time of transplantation with the goal of preventing acute rejection and ultimately inducing a tolerogenic state. The objective of this review is to examine specialized induction agents currently in clinical use and highlight novel therapeutics on the horizon for induction immunosuppression. Methods: A literature search using the PubMed and MEDLINE databases identified salient basic science and clinical research articles on induction immunosuppression for solid organ transplantation. Conclusions: While current induction immunosuppression agents have reduced the incidence of acute rejection, the goal of transplant tolerance has not been realized. Furthermore, the long-term allograft survival rate is not clearly influenced by the practice of induction immunosuppression. New approaches to tolerance induction, such as costimulatory-based therapy, mixed chimerism, and adoptive cellular transfer, hold promise for more effective induction immunosuppression in solid organ transplantation.

Original languageEnglish
Pages (from-to)515-524
Number of pages10
JournalAmerican Journal of Surgery
Issue number4
StatePublished - Apr 2009
Externally publishedYes


  • Induction immunosuppression
  • Solid organ transplantation
  • Tolerance


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