TY - JOUR
T1 - New Discorhabdin D Analogues from Latrunculia spp. Sponges
AU - Orfanoudaki, Maria
AU - Dalilian, Masoumeh
AU - Du, Lin
AU - Chau, Cindy H.
AU - Figg, William D.
AU - O’Keefe, Barry R.
AU - Grkovic, Tanja
N1 - Publisher Copyright:
U.S. Government. Not subject to U.S. Copyright. Published 2024 by American Chemical Society and American Society of Pharmacognosy.
PY - 2024/11/22
Y1 - 2024/11/22
N2 - Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.
AB - Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.
UR - http://www.scopus.com/inward/record.url?scp=85207409774&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.4c01036
DO - 10.1021/acs.jnatprod.4c01036
M3 - Article
C2 - 39453729
AN - SCOPUS:85207409774
SN - 0163-3864
VL - 87
SP - 2640
EP - 2648
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 11
ER -