New Discorhabdin D Analogues from Latrunculia spp. Sponges

Maria Orfanoudaki; Masoumeh Dalilian; Lin Du; Cindy H. Chau; William D. Figg; Barry R. O’Keefe; Tanja Grkovic

doi:10.1021/acs.jnatprod.4c01036

New Discorhabdin D Analogues from Latrunculia spp. Sponges

Maria Orfanoudaki, Masoumeh Dalilian, Lin Du, Cindy H. Chau, William D. Figg, Barry R. O’Keefe^*, Tanja Grkovic^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.

Original language	English
Pages (from-to)	2640-2648
Number of pages	9
Journal	Journal of Natural Products
Volume	87
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.4c01036
State	Published - 22 Nov 2024

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10.1021/acs.jnatprod.4c01036

Cite this

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title = "New Discorhabdin D Analogues from Latrunculia spp. Sponges",

abstract = "Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.",

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note = "Publisher Copyright: U.S. Government. Not subject to U.S. Copyright. Published 2024 by American Chemical Society and American Society of Pharmacognosy.",

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language = "English",

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T1 - New Discorhabdin D Analogues from Latrunculia spp. Sponges

AU - Orfanoudaki, Maria

AU - Dalilian, Masoumeh

AU - Du, Lin

AU - Chau, Cindy H.

AU - Figg, William D.

AU - O’Keefe, Barry R.

AU - Grkovic, Tanja

N1 - Publisher Copyright: U.S. Government. Not subject to U.S. Copyright. Published 2024 by American Chemical Society and American Society of Pharmacognosy.

PY - 2024/11/22

Y1 - 2024/11/22

N2 - Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.

AB - Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.

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