New insights into the regulation and cellular functions of the ARP2/3 complex

Jeremy D. Rotty; Congying Wu; James E. Bear

doi:10.1038/nrm3492

New insights into the regulation and cellular functions of the ARP2/3 complex

Jeremy D. Rotty, Congying Wu, James E. Bear^*

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Article › peer-review

404 Scopus citations

Abstract

The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.

Original language	English
Pages (from-to)	7-12
Number of pages	6
Journal	Nature Reviews Molecular Cell Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/nrm3492
State	Published - Jan 2013

Access to Document

10.1038/nrm3492

Cite this

@article{ab16475ab05c4e1e8c538171b54a7072,

title = "New insights into the regulation and cellular functions of the ARP2/3 complex",

abstract = "The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.",

author = "Rotty, {Jeremy D.} and Congying Wu and Bear, {James E.}",

year = "2013",

month = jan,

doi = "10.1038/nrm3492",

language = "English",

volume = "14",

pages = "7--12",

journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - New insights into the regulation and cellular functions of the ARP2/3 complex

AU - Rotty, Jeremy D.

AU - Wu, Congying

AU - Bear, James E.

PY - 2013/1

Y1 - 2013/1

N2 - The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.

AB - The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.

UR - http://www.scopus.com/inward/record.url?scp=84871519238&partnerID=8YFLogxK

U2 - 10.1038/nrm3492

DO - 10.1038/nrm3492

M3 - Article

C2 - 23212475

AN - SCOPUS:84871519238

SN - 1471-0072

VL - 14

SP - 7

EP - 12

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 1

ER -