New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli

Angela R. Melton-Celsa; Alison D. O'brien

doi:10.1128/9781555818791.ch17

New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli

Angela R. Melton-Celsa, Alison D. O'brien

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Shiga toxin (Stx)-producing Escherichia coli (STEC) colonizes the intestine and causes hemorrhagic colitis. STEC encodes a variety of colonization factors, but a significant subset of STEC, the enterohemorrhagic E. coli (EHEC) strains, have the locus of enterocyte effacement (LEE), the products of which allow the bacteria to intimately adhere to and form attaching and effacing lesions on intestinal tissue. The O157:H7 strains, which are responsible for the majority of large outbreaks due to STEC infection, are members of the EHEC group. All STEC strains make one or more Stxs; these pathogens may produce two immunologically distinct but highly similar Stxs, Stx1 and Stx2. These toxins are briefly described in the section on therapeutics targeted to the Stxs.

Original language	English
Title of host publication	Enterohemorrhagic Escherichia coli and Other Shiga Toxin-Producing E. coli
Publisher	wiley
Pages	341-358
Number of pages	18
ISBN (Electronic)	9781683670551
ISBN (Print)	9781119714200
DOIs	https://doi.org/10.1128/9781555818791.ch17
State	Published - 1 Jan 2015
Externally published	Yes

Keywords

Antibiotic treatment
Antibiotic use
Hemolytic uremic syndrome
Monoclonal antibodies
Shiga toxin-producing Escherichia coli
Therapeutic developments
Toxin binding

Access to Document

10.1128/9781555818791.ch17

Cite this

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title = "New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli",

abstract = "Shiga toxin (Stx)-producing Escherichia coli (STEC) colonizes the intestine and causes hemorrhagic colitis. STEC encodes a variety of colonization factors, but a significant subset of STEC, the enterohemorrhagic E. coli (EHEC) strains, have the locus of enterocyte effacement (LEE), the products of which allow the bacteria to intimately adhere to and form attaching and effacing lesions on intestinal tissue. The O157:H7 strains, which are responsible for the majority of large outbreaks due to STEC infection, are members of the EHEC group. All STEC strains make one or more Stxs; these pathogens may produce two immunologically distinct but highly similar Stxs, Stx1 and Stx2. These toxins are briefly described in the section on therapeutics targeted to the Stxs.",

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