New Views of Old Proteins: Clarifying the Enigmatic Proteome

Kristin E. Burnum-Johnson; Thomas P. Conrads; Richard R. Drake; Amy E. Herr; Ravi Iyengar; Ryan T. Kelly; Emma Lundberg; Michael J. MacCoss; Alexandra Naba; Garry P. Nolan; Pavel A. Pevzner; Karin D. Rodland; Salvatore Sechi; Nikolai Slavov; Jeffrey M. Spraggins; Jennifer E. Van Eyk; Marc Vidal; Christine Vogel; David R. Walt; Neil L. Kelleher

doi:10.1016/j.mcpro.2022.100254

New Views of Old Proteins: Clarifying the Enigmatic Proteome

Kristin E. Burnum-Johnson^*, Thomas P. Conrads, Richard R. Drake, Amy E. Herr, Ravi Iyengar, Ryan T. Kelly, Emma Lundberg, Michael J. MacCoss, Alexandra Naba, Garry P. Nolan, Pavel A. Pevzner, Karin D. Rodland, Salvatore Sechi, Nikolai Slavov, Jeffrey M. Spraggins, Jennifer E. Van Eyk, Marc Vidal, Christine Vogel, David R. Walt, Neil L. Kelleher^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

Original language	English
Article number	100254
Journal	Molecular and Cellular Proteomics
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.mcpro.2022.100254
State	Published - Jul 2022
Externally published	Yes

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Burnum-Johnson, K. E., Conrads, T. P., Drake, R. R., Herr, A. E., Iyengar, R., Kelly, R. T., Lundberg, E., MacCoss, M. J., Naba, A., Nolan, G. P., Pevzner, P. A., Rodland, K. D., Sechi, S., Slavov, N., Spraggins, J. M., Van Eyk, J. E., Vidal, M., Vogel, C., Walt, D. R., & Kelleher, N. L. (2022). New Views of Old Proteins: Clarifying the Enigmatic Proteome. Molecular and Cellular Proteomics, 21(7), Article 100254. https://doi.org/10.1016/j.mcpro.2022.100254

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title = "New Views of Old Proteins: Clarifying the Enigmatic Proteome",

abstract = "All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.",

author = "Burnum-Johnson, {Kristin E.} and Conrads, {Thomas P.} and Drake, {Richard R.} and Herr, {Amy E.} and Ravi Iyengar and Kelly, {Ryan T.} and Emma Lundberg and MacCoss, {Michael J.} and Alexandra Naba and Nolan, {Garry P.} and Pevzner, {Pavel A.} and Rodland, {Karin D.} and Salvatore Sechi and Nikolai Slavov and Spraggins, {Jeffrey M.} and {Van Eyk}, {Jennifer E.} and Marc Vidal and Christine Vogel and Walt, {David R.} and Kelleher, {Neil L.}",

note = "Publisher Copyright: {\textcopyright} 2022 THE AUTHORS.",

year = "2022",

month = jul,

doi = "10.1016/j.mcpro.2022.100254",

language = "English",

volume = "21",

journal = "Molecular and Cellular Proteomics",

issn = "1535-9476",

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Burnum-Johnson, KE, Conrads, TP, Drake, RR, Herr, AE, Iyengar, R, Kelly, RT, Lundberg, E, MacCoss, MJ, Naba, A, Nolan, GP, Pevzner, PA, Rodland, KD, Sechi, S, Slavov, N, Spraggins, JM, Van Eyk, JE, Vidal, M, Vogel, C, Walt, DR & Kelleher, NL 2022, 'New Views of Old Proteins: Clarifying the Enigmatic Proteome', Molecular and Cellular Proteomics, vol. 21, no. 7, 100254. https://doi.org/10.1016/j.mcpro.2022.100254

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T2 - Clarifying the Enigmatic Proteome

AU - Burnum-Johnson, Kristin E.

AU - Conrads, Thomas P.

AU - Drake, Richard R.

AU - Herr, Amy E.

AU - Iyengar, Ravi

AU - Kelly, Ryan T.

AU - Lundberg, Emma

AU - MacCoss, Michael J.

AU - Naba, Alexandra

AU - Nolan, Garry P.

AU - Pevzner, Pavel A.

AU - Rodland, Karin D.

AU - Sechi, Salvatore

AU - Slavov, Nikolai

AU - Spraggins, Jeffrey M.

AU - Van Eyk, Jennifer E.

AU - Vidal, Marc

AU - Vogel, Christine

AU - Walt, David R.

AU - Kelleher, Neil L.

PY - 2022/7

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AB - All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

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VL - 21

JO - Molecular and Cellular Proteomics

JF - Molecular and Cellular Proteomics

IS - 7

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ER -

New Views of Old Proteins: Clarifying the Enigmatic Proteome

Abstract

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