New world monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity

Franca R. Jones; Shahida Baqar; Alfonso Gozalo; Gladys Nunez; Nereyda Espinoza; Sharina M. Reyes; Milagros Salazar; Rina Meza; Chad K. Porter; Stephen E. Walz

doi:10.1128/IAI.74.1.790-793.2006

New world monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity

Franca R. Jones^*, Shahida Baqar, Alfonso Gozalo, Gladys Nunez, Nereyda Espinoza, Sharina M. Reyes, Milagros Salazar, Rina Meza, Chad K. Porter, Stephen E. Walz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.

Original language	English
Pages (from-to)	790-793
Number of pages	4
Journal	Infection and Immunity
Volume	74
Issue number	1
DOIs	https://doi.org/10.1128/IAI.74.1.790-793.2006
State	Published - Jan 2006
Externally published	Yes

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abstract = "Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.",

author = "Jones, {Franca R.} and Shahida Baqar and Alfonso Gozalo and Gladys Nunez and Nereyda Espinoza and Reyes, {Sharina M.} and Milagros Salazar and Rina Meza and Porter, {Chad K.} and Walz, {Stephen E.}",

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AU - Baqar, Shahida

AU - Gozalo, Alfonso

AU - Nunez, Gladys

AU - Espinoza, Nereyda

AU - Reyes, Sharina M.

AU - Salazar, Milagros

AU - Meza, Rina

AU - Porter, Chad K.

AU - Walz, Stephen E.

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AB - Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.

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New world monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity

Abstract

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