New world monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity

Franca R. Jones*, Shahida Baqar, Alfonso Gozalo, Gladys Nunez, Nereyda Espinoza, Sharina M. Reyes, Milagros Salazar, Rina Meza, Chad K. Porter, Stephen E. Walz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.

Original languageEnglish
Pages (from-to)790-793
Number of pages4
JournalInfection and Immunity
Volume74
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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