@article{d778d15455dd44268168dcb7638db442,
title = "NFAT5 contributes to the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and decrease of T regulatory cells in female mice",
abstract = "Multiple sclerosis disproportionally affects women. The present study was undertaken to determine whether NFAT5 contributed to the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, and if it did, whether the impact was sex associated. NFAT5 haplodeficiency reduced the disease severity only in female mice. This effect was associated with significant increases in frequency of T regulatory (Treg) cells in the CNS (from 1.45 ± 0.39% to 3.73 ± 0.94%) and spleen from (0.31 ± 0.06% to 0.94 ± 0.29%) without significantly affecting the CNS CD4+ subsets frequency. NFAT5 haploinsufficiency also significantly reduced the frequency of CD11c+CD8α+ dendritic cells in the female CNS. However, increase of their frequency in the CNS via intraperitoneal Flt3L injection at peak EAE had no significant effect on the disease courses. We conclude that NFAT5 contributes to pathogenesis of EAE in female mice, possibly through decreasing tissue specific frequency of Treg cells.",
keywords = "Autoimmunity, CD11cCD8α and Flt3L, CD4 cells, Dendritic cells, Multiple sclerosis, Neuroinflammation, Sex, TonEBP, Treg cells",
author = "Balamurugan Packialakshmi and Sharanpreet Hira and Kateryna Lund and Zhang, {Ai Hong} and Julia Halterman and Yuanyi Feng and Scott, {David W.} and Lees, {Jason R.} and Xiaoming Zhou",
note = "Funding Information: This work was funded in part by the grant (MED-83-3923) from the collaborative health initiative research program between the National Heart Lung and Blood Institute and the Henry Jackson Foundation for the Advancement of Military Medicine, the National Multiple Sclerosis Society, Grant PP3448 and the Department of Medicine at the Uniformed Services University of the Health Sciences. Authors thank Dr. Kevin K. Chung for his generous support. BP, AHZ, JRL, DWS and XZ: the conception and design of the study, BP, SH, KL, YF and XZ: acquisition of data, or analysis and interpretation of data, JH, DWS, JRL and XZ: drafting the article or revising it critically for important intellectual content, XZ: final approval of the version to be submitted. Funding Information: This work was funded in part by the grant (MED-83-3923) from the collaborative health initiative research program between the National Heart Lung and Blood Institute and the Henry Jackson Foundation for the Advancement of Military Medicine, the National Multiple Sclerosis Society, Grant PP3448 and the Department of Medicine at the Uniformed Services University of the Health Sciences. Authors thank Dr. Kevin K. Chung for his generous support. Publisher Copyright: {\textcopyright} 2022",
year = "2022",
month = may,
doi = "10.1016/j.cellimm.2022.104515",
language = "English",
volume = "375",
journal = "Cellular Immunology",
issn = "0008-8749",
}