Nitric oxide, a protective molecule in the cardiovascular system

Jing Lei; Yoram Vodovotz; Edith Tzeng; Timothy R. Billiar

doi:10.1016/j.niox.2013.09.004

Nitric oxide, a protective molecule in the cardiovascular system

Jing Lei^*, Yoram Vodovotz, Edith Tzeng, Timothy R. Billiar

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

154 Scopus citations

Abstract

Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.

Original language	English
Pages (from-to)	175-185
Number of pages	11
Journal	Nitric Oxide - Biology and Chemistry
Volume	35
DOIs	https://doi.org/10.1016/j.niox.2013.09.004
State	Published - 2013
Externally published	Yes

Keywords

Blood vessel injury
Endothelial cell
Intimal hyperplasia
Nitric oxide
Smooth muscle cell
Transplant vasculopathy

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10.1016/j.niox.2013.09.004

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title = "Nitric oxide, a protective molecule in the cardiovascular system",

abstract = "Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.",

keywords = "Blood vessel injury, Endothelial cell, Intimal hyperplasia, Nitric oxide, Smooth muscle cell, Transplant vasculopathy",

author = "Jing Lei and Yoram Vodovotz and Edith Tzeng and Billiar, {Timothy R.}",

year = "2013",

doi = "10.1016/j.niox.2013.09.004",

language = "English",

volume = "35",

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journal = "Nitric Oxide - Biology and Chemistry",

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T1 - Nitric oxide, a protective molecule in the cardiovascular system

AU - Lei, Jing

AU - Vodovotz, Yoram

AU - Tzeng, Edith

AU - Billiar, Timothy R.

PY - 2013

Y1 - 2013

N2 - Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.

AB - Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.

KW - Blood vessel injury

KW - Endothelial cell

KW - Intimal hyperplasia

KW - Nitric oxide

KW - Smooth muscle cell

KW - Transplant vasculopathy

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U2 - 10.1016/j.niox.2013.09.004

DO - 10.1016/j.niox.2013.09.004

M3 - Review article

C2 - 24095696

AN - SCOPUS:84887206478

SN - 1089-8603

VL - 35

SP - 175

EP - 185

JO - Nitric Oxide - Biology and Chemistry

JF - Nitric Oxide - Biology and Chemistry

ER -

Nitric oxide, a protective molecule in the cardiovascular system

Abstract

Keywords

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