Nitrogen oxide levels in patients after trauma and during sepsis

Juan B. Ochoa, Anthony O. Udekwu, Timothy R. Billiar, Ronald D. Curran, Frank B. Cerra, Richard L. Simmons, Andrew B. Peitzman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

577 Scopus citations

Abstract

The mediators responsible for maintenance of the hyperdynamic state and the low systemic vascular resistance (SVR) observed in sepsis have not been elucidated. Nitric oxide (· N = O) is a mediator with numerous functions, including regulation of vascular tone and a role in macrophage-mediated cytostasis and microbiostasis. Thirty-nine critically ill trauma and septic patients were studied to determine the relationship between · N = O production and the hyperdynamic state. High plasma levels of NO2-/NO3- (the stable end products of · N = O) were observed in septic patients (p < 0.02). Low SVR and high endotoxin levels were associated with high NO2-/NO3- values (p = 0.029, p = 0.002). Changes in · N = O levels may mediate the vasodilation seen in sepsis. Low NO2-/NO3- levels were observed in trauma patients (p < 0.001) and remained low even in the presence of sepsis (p = 0.001).

Original languageEnglish
Pages (from-to)621-626
Number of pages6
JournalAnnals of surgery
Volume214
Issue number5
DOIs
StatePublished - Nov 1991
Externally publishedYes

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