Nitrogen oxide levels in patients after trauma and during sepsis

Juan B. Ochoa; Anthony O. Udekwu; Timothy R. Billiar; Ronald D. Curran; Frank B. Cerra; Richard L. Simmons; Andrew B. Peitzman

doi:10.1097/00000658-199111000-00013

Nitrogen oxide levels in patients after trauma and during sepsis

Juan B. Ochoa, Anthony O. Udekwu, Timothy R. Billiar, Ronald D. Curran, Frank B. Cerra, Richard L. Simmons, Andrew B. Peitzman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

579 Scopus citations

Abstract

The mediators responsible for maintenance of the hyperdynamic state and the low systemic vascular resistance (SVR) observed in sepsis have not been elucidated. Nitric oxide (· N = O) is a mediator with numerous functions, including regulation of vascular tone and a role in macrophage-mediated cytostasis and microbiostasis. Thirty-nine critically ill trauma and septic patients were studied to determine the relationship between · N = O production and the hyperdynamic state. High plasma levels of NO2^-/NO₃^- (the stable end products of · N = O) were observed in septic patients (p < 0.02). Low SVR and high endotoxin levels were associated with high NO₂^-/NO₃^- values (p = 0.029, p = 0.002). Changes in · N = O levels may mediate the vasodilation seen in sepsis. Low NO₂^-/NO₃^- levels were observed in trauma patients (p < 0.001) and remained low even in the presence of sepsis (p = 0.001).

Original language	English
Pages (from-to)	621-626
Number of pages	6
Journal	Annals of surgery
Volume	214
Issue number	5
DOIs	https://doi.org/10.1097/00000658-199111000-00013
State	Published - Nov 1991
Externally published	Yes

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title = "Nitrogen oxide levels in patients after trauma and during sepsis",

abstract = "The mediators responsible for maintenance of the hyperdynamic state and the low systemic vascular resistance (SVR) observed in sepsis have not been elucidated. Nitric oxide (· N = O) is a mediator with numerous functions, including regulation of vascular tone and a role in macrophage-mediated cytostasis and microbiostasis. Thirty-nine critically ill trauma and septic patients were studied to determine the relationship between · N = O production and the hyperdynamic state. High plasma levels of NO2-/NO3- (the stable end products of · N = O) were observed in septic patients (p < 0.02). Low SVR and high endotoxin levels were associated with high NO2-/NO3- values (p = 0.029, p = 0.002). Changes in · N = O levels may mediate the vasodilation seen in sepsis. Low NO2-/NO3- levels were observed in trauma patients (p < 0.001) and remained low even in the presence of sepsis (p = 0.001).",

author = "Ochoa, {Juan B.} and Udekwu, {Anthony O.} and Billiar, {Timothy R.} and Curran, {Ronald D.} and Cerra, {Frank B.} and Simmons, {Richard L.} and Peitzman, {Andrew B.}",

year = "1991",

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doi = "10.1097/00000658-199111000-00013",

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volume = "214",

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T1 - Nitrogen oxide levels in patients after trauma and during sepsis

AU - Ochoa, Juan B.

AU - Udekwu, Anthony O.

AU - Billiar, Timothy R.

AU - Curran, Ronald D.

AU - Cerra, Frank B.

AU - Simmons, Richard L.

AU - Peitzman, Andrew B.

PY - 1991/11

Y1 - 1991/11

N2 - The mediators responsible for maintenance of the hyperdynamic state and the low systemic vascular resistance (SVR) observed in sepsis have not been elucidated. Nitric oxide (· N = O) is a mediator with numerous functions, including regulation of vascular tone and a role in macrophage-mediated cytostasis and microbiostasis. Thirty-nine critically ill trauma and septic patients were studied to determine the relationship between · N = O production and the hyperdynamic state. High plasma levels of NO2-/NO3- (the stable end products of · N = O) were observed in septic patients (p < 0.02). Low SVR and high endotoxin levels were associated with high NO2-/NO3- values (p = 0.029, p = 0.002). Changes in · N = O levels may mediate the vasodilation seen in sepsis. Low NO2-/NO3- levels were observed in trauma patients (p < 0.001) and remained low even in the presence of sepsis (p = 0.001).

AB - The mediators responsible for maintenance of the hyperdynamic state and the low systemic vascular resistance (SVR) observed in sepsis have not been elucidated. Nitric oxide (· N = O) is a mediator with numerous functions, including regulation of vascular tone and a role in macrophage-mediated cytostasis and microbiostasis. Thirty-nine critically ill trauma and septic patients were studied to determine the relationship between · N = O production and the hyperdynamic state. High plasma levels of NO2-/NO3- (the stable end products of · N = O) were observed in septic patients (p < 0.02). Low SVR and high endotoxin levels were associated with high NO2-/NO3- values (p = 0.029, p = 0.002). Changes in · N = O levels may mediate the vasodilation seen in sepsis. Low NO2-/NO3- levels were observed in trauma patients (p < 0.001) and remained low even in the presence of sepsis (p = 0.001).

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VL - 214

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EP - 626

JO - Annals of surgery

JF - Annals of surgery

IS - 5

ER -

Nitrogen oxide levels in patients after trauma and during sepsis

Abstract

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