No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight

D. L. Smith, H. T. Robertson, R. A. Desmond, T. R. Nagy, D. B. Allison

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor.Results and conclusion: Using data from a 2-year toxicology study of sibutramine in Sprague-Dawley CD rats and CD-1 mice, despite a dose-dependent reduction in food intake and body weight in rats compared with controls, and a body weight reduction in mice at the highest dose, there was no compelling evidence for reductions in mortality rate.

Original languageEnglish
Pages (from-to)652-657
Number of pages6
JournalInternational Journal of Obesity
Volume35
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • Meridia
  • anorexigens
  • caloric restriction
  • lifespan
  • survival
  • weight loss

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