Non-linear organic small molecule imaging agents

A. M. Armani*, Yasaman Moradi, Patrick Saris, Marko Lilic, Luciana Custer, Jerry Lee, Carolina Garri

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


From multi-photon to single molecule, the past several decades have witnessed a revolution in fluorescent microscopy. These techniques have revealed the inner working of cells and tissue and have relied on symbiotic advances in advanced molecular probes, light emitting molecules and particles, and novel instrumentation. Following on these developments, researchers began to develop functional nanomaterials or materials that can response to their environment. One of the first such molecules reported electric fields, allowing neuron signaling to be observed. However, the optical signal generated by voltage reporters is often low, placing limitations on the measurements that can be performed. Thus, material scientists and chemists began to pursue the development of alternative systems. In parallel, the fields of organic solar cells and integrated photonics were actively pursuing the design of materials with similar active properties, thus forming a foundation for improved functional organic imaging agents. In this talk, I will discuss some of our recent work in developing functional imaging agents for multi-wavelength and multi-photon live-cell imaging, focusing on recent molecular designs performed using density functional theory as well as in vitro studies.

Original languageEnglish
Title of host publicationSingle Molecule Spectroscopy and Superresolution Imaging XVI
EditorsIngo Gregor, Felix Koberling, Rainer Erdmann
ISBN (Electronic)9781510658776
StatePublished - 2023
Externally publishedYes
EventSingle Molecule Spectroscopy and Superresolution Imaging XVI 2023 - San Francisco, United States
Duration: 28 Jan 202329 Jan 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceSingle Molecule Spectroscopy and Superresolution Imaging XVI 2023
Country/TerritoryUnited States
CitySan Francisco


  • fluorescent imaging
  • nonlinear material
  • organic dye


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