Nonalcoholic fatty liver disease and extra-hepatic malignancy

Dustin M. Albert, Dawn M. Torres*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Nonalcoholic fatty liver disease (NAFLD) has risen to become the most common cause of chronic liver disease in Western nations in concert with rising rates of obesity. The majority of patients with NAFLD meet criteria for the metabolic syndrome and are often found to have insulin resistance (IR) or frank diabetes along with increased rates of cardiovascular disease, overall mortality, and primary hepatocellular carcinoma (HCC). The association of NAFLD with cancer specifically is an area of more recent investigation with the majority of data coming indirectly from population based studies linking obesity and a variety of extra-hepatic malignancies. Research specifically linking NAFLD with cancer has been limited to colorectal adenomas and colorectal cancer (CRC), with the majority of data showing an increased prevalence of both in NAFLD populations.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalCurrent Hepatitis Reports
Issue number2
StatePublished - Jun 2014
Externally publishedYes


  • Cancer prevalence
  • Colon adenomas
  • Colon polyps
  • Colorectal cancer
  • Fatty liver
  • Insulin resistance
  • Metabolic syndrome
  • Obesity
  • Steatosis


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