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Nonamperometric CMOS sensing of intestinal action potentials

Yingqiu Cao*, Nikolai Rakhilin, Xiling Shen, Edwin C. Kan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A CMOS floating-gate, non-amperometric electrochemical sensor, which overcomes the invasiveness of patch-clamp and bias-setting of Ion Sensitive FET (ISFET), is proposed to detect enteric nerve system (ENS) action potentials (AP) by model-based match filtering. With the cellular HodgkinHuxley (HH) models of S-type and AH-type neurons, we robustly capture AP from freshly harvested mouse intestinal tissues.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2064-2066
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Chemoreceptive neuron MOS (CvMOS) sensor
  • Intestinal action potential

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