Noninvasive potassium measurements from ECG analysis during hemodialysis sessions

Severi Severi*, C. Corsi, M. Haigney, J. DeBie, D. Mortara

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Scopus citations

Abstract

It is well known that blood potassium concentration [K+] has a strong influence on ECG signal and particularly on T-wave morphology. No quantitative relations between parameters derived from ECG analysis and potassium levels in the blood have been established for clinical use. We developed a new method to quantify [K+] from T-wave analysis in real-time and tested it on data from dialysis patients, in which [K+] varies significantly during the session. The agreement between ECG-based potassium estimator and the reference potassium measurements was good (absolute error: 0.49±0.16 mM) for most of the sessions (30/39) except for 9 (absolute error: 1.17±0.36 mM) in which the presence of a systematic error all along the session did not allow reliable estimates. Bland-Altman analysis showed that the overall systematic error was almost null (-0.03 mM) whereas the standard deviation was 0.83 mM. The manual correction of the bias over each dialysis session resulted in excellent results for all patients. Preliminary results are promising although further investigation is required to understand the reason for session-dependent bias in some patients.

Original languageEnglish
Title of host publicationComputers in Cardiology 2009, CinC 2009
Pages821-824
Number of pages4
StatePublished - 2009
Externally publishedYes
Event36th Annual Conference of Computers in Cardiology, CinC 2009 - Park City, UT, United States
Duration: 13 Sep 200916 Sep 2009

Publication series

NameComputers in Cardiology
Volume36
ISSN (Print)0276-6574

Conference

Conference36th Annual Conference of Computers in Cardiology, CinC 2009
Country/TerritoryUnited States
CityPark City, UT
Period13/09/0916/09/09

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