North American Clinical Trials Network for Spinal Cord Injury Registry: Methodology and Analysis

Elizabeth G. Toups*, Beatrice Ugiliweneza, Susan P. Howley, Chris J. Neal, James S. Harrop, James D. Guest, Robert G. Grossman, Michael G. Fehlings

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The North American Clinical Trials Network (NACTN) for Spinal Cord Injury (SCI) is a consortium of neurosurgery departments at university affiliated hospitals with medical, nursing, and rehabilitation personnel who are skilled in the assessment, evaluation, and management of SCI. NACTN was established with the goal of consistently advancing the quality of life of people with SCI through clinical trials of new therapies that provide robust evidence of safety and effectiveness. A prospective multi-center Registry was created to collect the natural course of the acute traumatic SCI patient from time of injury to 12 months follow-up. NACTN's network of hospitals enrolls a significant number of patients, defines and adheres to standard protocols, and provides the infrastructure and highly skilled personnel to conduct trials of therapy for SCI. Registry data have been used by academic institutions and by the biotechnology and pharmaceutical sectors to create comparison datasets for Phase I clinical trials of new therapies.

Original languageEnglish
Pages (from-to)1817-1822
Number of pages6
JournalJournal of Neurotrauma
Volume40
Issue number17-18
DOIs
StatePublished - 1 Sep 2023
Externally publishedYes

Keywords

  • ASIA Impairment Score
  • International Standards for Neurological Classification of Spinal Cord Injury
  • data management
  • registry
  • spinal cord injury

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