Abstract
A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, AFS has a unique pathophysiology. Patients with AFS demonstrate type 1 hypersensitivity to fungal allergens, increased total serum IgE, increased CD8(+) T-cell prevalence, and IL-4 and IL-5 response. Omalizumab should be considered in the treatment of AFS.
| Original language | English |
|---|---|
| Pages (from-to) | 172-4 |
| Number of pages | 3 |
| Journal | Allergy and Rhinology |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 2014 |