Novel unsaturated purine nucleosides

Vasu Nair*, Lyons Arthur G

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The synthesis of a number of novel purine ribonucleosides bearing one degree of unsaturation at the 2-position is described. The two key reactions used in the synthesis of these compounds is a palladium-catalyzed cross-coupling reaction and an ozonolysis. These synthetic transformations have rarely been used in nucleoside chemistry. Isomerization of an allylpurine system to a vinylpurine system under the conditions of the cross-coupling reaction and also under fluoride ion catalysis is discussed. The novel 2-formylpurine nucleosides described appear to be easily hydrated.

Original languageEnglish
Pages (from-to)3653-3662
Number of pages10
Issue number12
StatePublished - 1989
Externally publishedYes


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