NSC243928 Treatment Induces Anti-Tumor Immune Response in Mouse Mammary Tumor Models

Benson Chellakkan Selvanesan, Alvaro de Mingo Pulido, Sheelu Varghese, Deepak Rohila, Daniel Hupalo, Yuriy Gusev, Sara Contente, Matthew D. Wilkerson, Clifton L. Dalgard, Geeta Upadhyay*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

NSC243928 induces cell death in triple-negative breast cancer cells in a LY6K-dependent manner. NSC243928 has been reported as an anti-cancer agent in the NCI small molecule library. The molecular mechanism of NSC243928 as an anti-cancer agent in the treatment of tumor growth in the syngeneic mouse model has not been established. With the success of immunotherapies, novel anti-cancer drugs that may elicit an anti-tumor immune response are of high interest in the development of novel drugs to treat solid cancer. Thus, we focused on studying whether NSC243928 may elicit an anti-tumor immune response in the in vivo mammary tumor models of 4T1 and E0771. We observed that NSC243928 induced immunogenic cell death in 4T1 and E0771 cells. Furthermore, NSC243928 mounted an anti-tumor immune response by increasing immune cells such as patrolling monocytes, NKT cells, B1 cells, and decreasing PMN MDSCs in vivo. Further studies are required to understand the exact mechanism of NSC243928 action in inducing an anti-tumor immune response in vivo, which can be used to determine a molecular signature associated with NSC243928 efficacy. NSC243928 may be a good target for future immuno-oncology drug development for breast cancer.

Original languageEnglish
Article number1468
JournalCancers
Volume15
Issue number5
DOIs
StatePublished - Mar 2023
Externally publishedYes

Keywords

  • 4T1
  • B1 cells
  • E0771
  • LY6K
  • NKT cells
  • NSC243928
  • mammary tumor model
  • myeloid derived suppressor cells

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