Obesity and headache: Part II - Potential mechanism and treatment considerations

Nu Cindy Chai, Dale S. Bond, Abhay Moghekar, Ann I. Scher, B. Lee Peterlin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Obesity and headache are both associated with a substantial personal and societal impact, and epidemiologic studies have consistently identified a positive association between obesity and headache in general, as well as obesity and migraine specifically (see part I). In the current manuscript, we will discuss the potential mechanisms for the migraine-obesity association, with a focus on the central and peripheral pathophysiological pathways which overlap between migraine and those modulating the drive to feed. We then discuss surgical, behavioral, and pharmacological treatment considerations for overweight and obese migraineurs as well as for those with idiopathic intracranial hypertension. We close by briefly discussing where future research may be headed in light of this data.

Original languageEnglish
Pages (from-to)459-471
Number of pages13
Issue number3
StatePublished - Mar 2014
Externally publishedYes


  • body mass index
  • headache
  • migraine
  • obesity


Dive into the research topics of 'Obesity and headache: Part II - Potential mechanism and treatment considerations'. Together they form a unique fingerprint.

Cite this