Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family

Esther H. Chang; Kathleen F. Pirollo; Zhi Qiang Zou; Hon Yeung Cheung; Elsbeth Lee Lawler; Rosa Garner; Elizabeth White; Wendy B. Bernstein; Joseph W. Fraumeni; William A. Blattner

doi:10.1126/science.3616624

Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family

Esther H. Chang^*, Kathleen F. Pirollo, Zhi Qiang Zou, Hon Yeung Cheung, Elsbeth Lee Lawler, Rosa Garner, Elizabeth White, Wendy B. Bernstein, Joseph W. Fraumeni, William A. Blattner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.

Original language	English
Pages (from-to)	1036-1039
Number of pages	4
Journal	Science
Volume	237
Issue number	4818
DOIs	https://doi.org/10.1126/science.3616624
State	Published - 1987
Externally published	Yes

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@article{15bb231c31504a89809d2d11f063ab90,

title = "Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family",

abstract = "Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.",

author = "Chang, {Esther H.} and Pirollo, {Kathleen F.} and Zou, {Zhi Qiang} and Cheung, {Hon Yeung} and Lawler, {Elsbeth Lee} and Rosa Garner and Elizabeth White and Bernstein, {Wendy B.} and Fraumeni, {Joseph W.} and Blattner, {William A.}",

year = "1987",

doi = "10.1126/science.3616624",

language = "English",

volume = "237",

pages = "1036--1039",

journal = "Science",

issn = "0036-8075",

number = "4818",

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TY - JOUR

T1 - Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family

AU - Chang, Esther H.

AU - Pirollo, Kathleen F.

AU - Zou, Zhi Qiang

AU - Cheung, Hon Yeung

AU - Lawler, Elsbeth Lee

AU - Garner, Rosa

AU - White, Elizabeth

AU - Bernstein, Wendy B.

AU - Fraumeni, Joseph W.

AU - Blattner, William A.

PY - 1987

Y1 - 1987

N2 - Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.

AB - Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.

UR - http://www.scopus.com/inward/record.url?scp=0023219306&partnerID=8YFLogxK

U2 - 10.1126/science.3616624

DO - 10.1126/science.3616624

M3 - Article

C2 - 3616624

AN - SCOPUS:0023219306

SN - 0036-8075

VL - 237

SP - 1036

EP - 1039

JO - Science

JF - Science

IS - 4818

ER -

Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family

Abstract

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