Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family

Esther H. Chang*, Kathleen F. Pirollo, Zhi Qiang Zou, Hon Yeung Cheung, Elsbeth Lee Lawler, Rosa Garner, Elizabeth White, Wendy B. Bernstein, Joseph W. Fraumeni, William A. Blattner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.

Original languageEnglish
Pages (from-to)1036-1039
Number of pages4
Issue number4818
StatePublished - 1987
Externally publishedYes


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