Optimal Strategies for Severe Acute Respiratory Distress Syndrome

Jeremy W. Cannon*, Jacob T. Gutsche, Daniel Brodie

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Acute respiratory distress syndrome (ARDS) occurs in more than 10% of intensive care unit admissions and in nearly 25% of ventilated patients. Mortality remains high at 40%, and, for patients who survive, recovery continues for months or even years. Early recognition and minimizing further lung injury remain essential to successful management of severe ARDS. Advanced treatment strategies, which complement lung protective ventilation, include short-term neuromuscular blockade, prone positioning, and extracorporeal membrane oxygenation. Alternative ventilator strategies include high-frequency ventilation and airway pressure release ventilation. This article reviews these options in patients with severe ARDS.

Original languageEnglish
Pages (from-to)259-275
Number of pages17
JournalCritical Care Clinics
Issue number2
StatePublished - 1 Apr 2017
Externally publishedYes


  • Acute respiratory distress syndrome
  • Extracorporeal membrane oxygenation
  • High-frequency oscillatory ventilation
  • Lung protective ventilation
  • Neuromuscular blockade
  • Physical conditioning
  • Prone positioning
  • Pulmonary vasodilators


Dive into the research topics of 'Optimal Strategies for Severe Acute Respiratory Distress Syndrome'. Together they form a unique fingerprint.

Cite this