Optimal Strategies for Severe Acute Respiratory Distress Syndrome

Jeremy W. Cannon; Jacob T. Gutsche; Daniel Brodie

doi:10.1016/j.ccc.2016.12.010

Optimal Strategies for Severe Acute Respiratory Distress Syndrome

Jeremy W. Cannon^*, Jacob T. Gutsche, Daniel Brodie

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Acute respiratory distress syndrome (ARDS) occurs in more than 10% of intensive care unit admissions and in nearly 25% of ventilated patients. Mortality remains high at 40%, and, for patients who survive, recovery continues for months or even years. Early recognition and minimizing further lung injury remain essential to successful management of severe ARDS. Advanced treatment strategies, which complement lung protective ventilation, include short-term neuromuscular blockade, prone positioning, and extracorporeal membrane oxygenation. Alternative ventilator strategies include high-frequency ventilation and airway pressure release ventilation. This article reviews these options in patients with severe ARDS.

Original language	English
Pages (from-to)	259-275
Number of pages	17
Journal	Critical Care Clinics
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.ccc.2016.12.010
State	Published - 1 Apr 2017
Externally published	Yes

Keywords

Acute respiratory distress syndrome
Extracorporeal membrane oxygenation
High-frequency oscillatory ventilation
Lung protective ventilation
Neuromuscular blockade
Physical conditioning
Prone positioning
Pulmonary vasodilators

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title = "Optimal Strategies for Severe Acute Respiratory Distress Syndrome",

abstract = "Acute respiratory distress syndrome (ARDS) occurs in more than 10% of intensive care unit admissions and in nearly 25% of ventilated patients. Mortality remains high at 40%, and, for patients who survive, recovery continues for months or even years. Early recognition and minimizing further lung injury remain essential to successful management of severe ARDS. Advanced treatment strategies, which complement lung protective ventilation, include short-term neuromuscular blockade, prone positioning, and extracorporeal membrane oxygenation. Alternative ventilator strategies include high-frequency ventilation and airway pressure release ventilation. This article reviews these options in patients with severe ARDS.",

keywords = "Acute respiratory distress syndrome, Extracorporeal membrane oxygenation, High-frequency oscillatory ventilation, Lung protective ventilation, Neuromuscular blockade, Physical conditioning, Prone positioning, Pulmonary vasodilators",

author = "Cannon, {Jeremy W.} and Gutsche, {Jacob T.} and Daniel Brodie",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2017",

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doi = "10.1016/j.ccc.2016.12.010",

language = "English",

volume = "33",

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T1 - Optimal Strategies for Severe Acute Respiratory Distress Syndrome

AU - Cannon, Jeremy W.

AU - Gutsche, Jacob T.

AU - Brodie, Daniel

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Acute respiratory distress syndrome (ARDS) occurs in more than 10% of intensive care unit admissions and in nearly 25% of ventilated patients. Mortality remains high at 40%, and, for patients who survive, recovery continues for months or even years. Early recognition and minimizing further lung injury remain essential to successful management of severe ARDS. Advanced treatment strategies, which complement lung protective ventilation, include short-term neuromuscular blockade, prone positioning, and extracorporeal membrane oxygenation. Alternative ventilator strategies include high-frequency ventilation and airway pressure release ventilation. This article reviews these options in patients with severe ARDS.

AB - Acute respiratory distress syndrome (ARDS) occurs in more than 10% of intensive care unit admissions and in nearly 25% of ventilated patients. Mortality remains high at 40%, and, for patients who survive, recovery continues for months or even years. Early recognition and minimizing further lung injury remain essential to successful management of severe ARDS. Advanced treatment strategies, which complement lung protective ventilation, include short-term neuromuscular blockade, prone positioning, and extracorporeal membrane oxygenation. Alternative ventilator strategies include high-frequency ventilation and airway pressure release ventilation. This article reviews these options in patients with severe ARDS.

KW - Acute respiratory distress syndrome

KW - Extracorporeal membrane oxygenation

KW - High-frequency oscillatory ventilation

KW - Lung protective ventilation

KW - Neuromuscular blockade

KW - Physical conditioning

KW - Prone positioning

KW - Pulmonary vasodilators

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U2 - 10.1016/j.ccc.2016.12.010

DO - 10.1016/j.ccc.2016.12.010

M3 - Review article

C2 - 28284294

AN - SCOPUS:85014600309

SN - 0749-0704

VL - 33

SP - 259

EP - 275

JO - Critical Care Clinics

JF - Critical Care Clinics

IS - 2

ER -

Optimal Strategies for Severe Acute Respiratory Distress Syndrome

Abstract

Keywords

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