Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation

T. Jensen; J. Baas; A. Dolathshahi-Pirouz; T. Jacobsen; G. Singh; J. V. Nygaard; M. Foss; J. Bechtold; C. Bünger; F. Besenbacher; K. Søballe

doi:10.1002/jbm.a.33166

Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation

T. Jensen^*, J. Baas, A. Dolathshahi-Pirouz, T. Jacobsen, G. Singh, J. V. Nygaard, M. Foss, J. Bechtold, C. Bünger, F. Besenbacher, K. Søballe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix of poly-D,L-lactic-acid (PDLLA). In a canine endosseus 0.75-mm gap implant model, we tested the osteointegrative impact of the OPN functionalized composite as an implant coating, and a non-functionalized composite was used as reference control. During the four weeks of observation, the OPN functionalized composite coating significantly increased the formation of new bone in the porosities of the implant, but no differences were observed in the gap. The study provides evidence of its potential use either alone or in combination with other osteoconductive compounds.

Original language	English
Pages (from-to)	94-101
Number of pages	8
Journal	Journal of Biomedical Materials Research - Part A
Volume	99 A
Issue number	1
DOIs	https://doi.org/10.1002/jbm.a.33166
State	Published - Oct 2011
Externally published	Yes

Keywords

biocompatibility
composite
hydroxyapatite
osteointegration
osteopontin

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Jensen, T., Baas, J., Dolathshahi-Pirouz, A., Jacobsen, T., Singh, G., Nygaard, J. V., Foss, M., Bechtold, J., Bünger, C., Besenbacher, F., & Søballe, K. (2011). Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation. Journal of Biomedical Materials Research - Part A, 99 A(1), 94-101. https://doi.org/10.1002/jbm.a.33166

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abstract = "We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix of poly-D,L-lactic-acid (PDLLA). In a canine endosseus 0.75-mm gap implant model, we tested the osteointegrative impact of the OPN functionalized composite as an implant coating, and a non-functionalized composite was used as reference control. During the four weeks of observation, the OPN functionalized composite coating significantly increased the formation of new bone in the porosities of the implant, but no differences were observed in the gap. The study provides evidence of its potential use either alone or in combination with other osteoconductive compounds.",

keywords = "biocompatibility, composite, hydroxyapatite, osteointegration, osteopontin",

author = "T. Jensen and J. Baas and A. Dolathshahi-Pirouz and T. Jacobsen and G. Singh and Nygaard, {J. V.} and M. Foss and J. Bechtold and C. B{\"u}nger and F. Besenbacher and K. S{\o}balle",

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Jensen, T, Baas, J, Dolathshahi-Pirouz, A, Jacobsen, T, Singh, G, Nygaard, JV, Foss, M, Bechtold, J, Bünger, C, Besenbacher, F & Søballe, K 2011, 'Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation', Journal of Biomedical Materials Research - Part A, vol. 99 A, no. 1, pp. 94-101. https://doi.org/10.1002/jbm.a.33166

TY - JOUR

T1 - Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation

AU - Jensen, T.

AU - Baas, J.

AU - Dolathshahi-Pirouz, A.

AU - Jacobsen, T.

AU - Singh, G.

AU - Nygaard, J. V.

AU - Foss, M.

AU - Bechtold, J.

AU - Bünger, C.

AU - Besenbacher, F.

AU - Søballe, K.

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N2 - We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix of poly-D,L-lactic-acid (PDLLA). In a canine endosseus 0.75-mm gap implant model, we tested the osteointegrative impact of the OPN functionalized composite as an implant coating, and a non-functionalized composite was used as reference control. During the four weeks of observation, the OPN functionalized composite coating significantly increased the formation of new bone in the porosities of the implant, but no differences were observed in the gap. The study provides evidence of its potential use either alone or in combination with other osteoconductive compounds.

AB - We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix of poly-D,L-lactic-acid (PDLLA). In a canine endosseus 0.75-mm gap implant model, we tested the osteointegrative impact of the OPN functionalized composite as an implant coating, and a non-functionalized composite was used as reference control. During the four weeks of observation, the OPN functionalized composite coating significantly increased the formation of new bone in the porosities of the implant, but no differences were observed in the gap. The study provides evidence of its potential use either alone or in combination with other osteoconductive compounds.

KW - biocompatibility

KW - composite

KW - hydroxyapatite

KW - osteointegration

KW - osteopontin

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Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation

Abstract

Keywords

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