Oxalate nephropathy after continuous infusion of high-dose Vitamin C as an adjunct to burn resuscitation

Michelle Buehner*, Jeremy Pamplin, Lynette Studer, Rhome L. Hughes, Booker T. King, John C. Graybill, Kevin K. Chung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Fluid resuscitation is the foundation of management in burn patients and is the topic of considerable research. One adjunct in burn resuscitation is continuous, high-dose vitamin C (ascorbic acid) infusion, which may reduce fluid requirements and thus decrease the risk for over resuscitation. Research in preclinical studies and clinical trials has shown continuous infusions of high-dose vitamin C to be beneficial with decrease in resuscitative volumes and limited adverse effects. However, high-dose and low-dose vitamin C supplementation has been shown to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients. To the best of our knowledge, the authors present the first case series in burn patients in whom calcium oxalate nephropathy has been identified after high-dose vitamin C therapy.

Original languageEnglish
Pages (from-to)e374-e379
JournalJournal of Burn Care and Research
Volume37
Issue number4
DOIs
StatePublished - 1 Aug 2016
Externally publishedYes

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