@article{0c1f7643c920475197231b3c049afec4,
title = "Oxaliplatin-induced peripheral neuropathy can be minimized by pressurized regional intravascular delivery in an orthotopic murine pancreatic cancer model",
abstract = "Purpose: There is a great need to reduce the toxicity of chemotherapy used in the management of pancreatic ductal adenocarcinoma (PDAC). Here we explore if regional pressurized delivery of oxaliplatin can minimize peripheral neuropathy in mice. Methods: We used an orthotopic PDAC mouse model and delivered a single dose of oxaliplatin through the portal vein using a pressure-enabled system (pancreatic retrograde venous infusion, PRVI). We analyzed the effects of PRVI on tumor burden and peripheral neuropathy using histopathological and functional assays. Results: Tumor weights in mice treated with 2 mg/kg oxaliplatin using PRVI were significantly lower than in mice treated with the same dose systemically. This resulted in reduced peripheral neuropathy signatures in PRVI mice compared to the 20 mg/kg systemic dose required to achieve similar tumor control. Conclusion: Regional delivery of highly cytotoxic agents using PRVI can reduce the therapeutic dose of these drugs, thereby lowering toxic side effects.",
author = "{Shankara Narayanan}, {Jayanth Surya Narayanan} and Katie Frizzi and Suna Erdem and Partha Ray and David Jaroch and Bryan Cox and Steven Katz and Diego Vicente and Rebekah White",
note = "Funding Information: We would like to acknowledge Prof. Nigel Calcutt, Department of Pathology, UCSD, and Dr. Neal Arakawa, Environmental and Complex Analysis Laboratory (ECAL), UCSD, for their inputs to this study. This study was partly funded by TriSalus{\texttrademark} Life Sciences, Inc., Westminster, CO, USA. Funding Information: We would like to acknowledge Prof. Nigel Calcutt, Department of Pathology, UCSD, and Dr. Neal Arakawa, Environmental and Complex Analysis Laboratory (ECAL), UCSD, for their inputs to this study. This study was partly funded by TriSalus? Life Sciences, Inc., Westminster, CO, USA. USU-WRNMMC Surgery: The opinions or assertions contained herein are the private ones of the author/speaker and are not to be construed as official or reflecting the views of the Department of Defense, the Uniformed Services University of the Health Sciences, or any other agency of the US Government. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1007/s12672-022-00483-4",
language = "English",
volume = "13",
journal = "Discover Oncology",
issn = "2730-6011",
number = "1",
}