Oxidative stress induces proorphanin FQ and proenkephalin gene expression in astrocytes through p38- and ERK-MAP kinases and NF-κB

Medicine & Life Sciences

• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 16%
• 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 20%
• Astrocytes 44%
• Brain Diseases 6%
• Cyclic AMP Response Element-Binding Protein 17%
• Enkephalins 8%
• Extracellular Signal-Regulated MAP Kinases 52%
• Gene Expression 28%
• Genes 8%
• Hydrogen Peroxide 6%
• Hypoxia 5%
• Immunohistochemistry 4%
• Messenger RNA 11%
• Neurodegenerative Diseases 5%
• Neuroglia 6%
• Neuropeptides 7%
• nociceptin 10%
• Opioid Analgesics 12%
• Oxidative Stress 35%
• p38 Mitogen-Activated Protein Kinases 49%
• Phosphorylation 9%
• proenkephalin 73%
• pronociceptin 100%
• Reactive Oxygen Species 11%
• Stroke 4%
• Therapeutics 2%
• Transcription Factors 5%
• Traumatic Brain Injury 6%
• Western Blotting 4%
• Wounds and Injuries 3%

Chemistry

• Hydrogen Peroxide 9%
• Oxidative Stress 47%
• Protein 4%
• Reactive Oxygen Metabolite 22%