PAC-1: A mitogen-induced nuclear protein tyrosine phosphatase

Patricia J. Rohan; Paula Davis; Christopher A. Moskaluk; Mary Kearns; Henry Krutzsch; Ulrich Siebenlist; Kathleen Kelly

doi:10.1126/science.7681221

PAC-1: A mitogen-induced nuclear protein tyrosine phosphatase

Patricia J. Rohan, Paula Davis, Christopher A. Moskaluk, Mary Kearns, Henry Krutzsch, Ulrich Siebenlist, Kathleen Kelly^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

287 Scopus citations

Abstract

Tyrosine phosphorylation of proteins is required for signal transaction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock In fibroblasts, a yeast gene, and a vaccinia virus - encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.

Original language	English
Pages (from-to)	1763-1766
Number of pages	4
Journal	Science
Volume	259
Issue number	5102
DOIs	https://doi.org/10.1126/science.7681221
State	Published - 1993
Externally published	Yes

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title = "PAC-1: A mitogen-induced nuclear protein tyrosine phosphatase",

abstract = "Tyrosine phosphorylation of proteins is required for signal transaction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock In fibroblasts, a yeast gene, and a vaccinia virus - encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.",

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T2 - A mitogen-induced nuclear protein tyrosine phosphatase

AU - Rohan, Patricia J.

AU - Davis, Paula

AU - Moskaluk, Christopher A.

AU - Kearns, Mary

AU - Krutzsch, Henry

AU - Siebenlist, Ulrich

AU - Kelly, Kathleen

PY - 1993

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N2 - Tyrosine phosphorylation of proteins is required for signal transaction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock In fibroblasts, a yeast gene, and a vaccinia virus - encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.

AB - Tyrosine phosphorylation of proteins is required for signal transaction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock In fibroblasts, a yeast gene, and a vaccinia virus - encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.

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PAC-1: A mitogen-induced nuclear protein tyrosine phosphatase

Abstract

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