PAC-1: A mitogen-induced nuclear protein tyrosine phosphatase

Patricia J. Rohan, Paula Davis, Christopher A. Moskaluk, Mary Kearns, Henry Krutzsch, Ulrich Siebenlist, Kathleen Kelly*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

286 Scopus citations

Abstract

Tyrosine phosphorylation of proteins is required for signal transaction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock In fibroblasts, a yeast gene, and a vaccinia virus - encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.

Original languageEnglish
Pages (from-to)1763-1766
Number of pages4
JournalScience
Volume259
Issue number5102
DOIs
StatePublished - 1993
Externally publishedYes

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