Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Patrick M. McGann; Matthew R. Geringer; Lindsey R. Hall; Francois Lebreton; Elizabeth Markelz; Yoon I. Kwak; Sheila Johnson; Ana C. Ong; Aubrey Powell; Tsigereda Tekle; Yehudit Bergman; Patricia J. Simner; Jason W. Bennett; Robert J. Cybulski; Brian K. White

doi:10.1099/jmm.0.001406

Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Patrick M. McGann^*
, Matthew R. Geringer
, Lindsey R. Hall
, Francois Lebreton
, Elizabeth Markelz
, Yoon I. Kwak
, Sheila Johnson
, Ana C. Ong
, Aubrey Powell
, Tsigereda Tekle
, Yehudit Bergman
, Patricia J. Simner
, Jason W. Bennett
, Robert J. Cybulski
, Brian K. White^*

^*Corresponding author for this work

Walter Reed Army Institute of Research (WRAIR)

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase blaNDM-1, the extended-spectrum β-lactamase blaPER-1, and the rare 16S methyltransferase rmtB2.

Original language	English
Article number	001406
Journal	Journal of Medical Microbiology
Volume	70
Issue number	8
DOIs	https://doi.org/10.1099/jmm.0.001406
State	Published - 2021

Keywords

COVID-19
Cefiderocol resistance
NDM carbapenemase
Providencia rettgeri

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McGann, P. M., Geringer, M. R., Hall, L. R., Lebreton, F., Markelz, E., Kwak, Y. I., Johnson, S., Ong, A. C., Powell, A., Tekle, T., Bergman, Y., Simner, P. J., Bennett, J. W., Cybulski, R. J., & White, B. K. (2021). Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19. Journal of Medical Microbiology, 70(8), Article 001406. https://doi.org/10.1099/jmm.0.001406

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title = "Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19",

abstract = "Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase blaNDM-1, the extended-spectrum β-lactamase blaPER-1, and the rare 16S methyltransferase rmtB2.",

keywords = "COVID-19, Cefiderocol resistance, NDM carbapenemase, Providencia rettgeri",

author = "McGann, \{Patrick M.\} and Geringer, \{Matthew R.\} and Hall, \{Lindsey R.\} and Francois Lebreton and Elizabeth Markelz and Kwak, \{Yoon I.\} and Sheila Johnson and Ong, \{Ana C.\} and Aubrey Powell and Tsigereda Tekle and Yehudit Bergman and Simner, \{Patricia J.\} and Bennett, \{Jason W.\} and Cybulski, \{Robert J.\} and White, \{Brian K.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors.",

year = "2021",

doi = "10.1099/jmm.0.001406",

language = "English",

volume = "70",

journal = "Journal of Medical Microbiology",

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AU - McGann, Patrick M.

AU - Geringer, Matthew R.

AU - Hall, Lindsey R.

AU - Lebreton, Francois

AU - Markelz, Elizabeth

AU - Kwak, Yoon I.

AU - Johnson, Sheila

AU - Ong, Ana C.

AU - Powell, Aubrey

AU - Tekle, Tsigereda

AU - Bergman, Yehudit

AU - Simner, Patricia J.

AU - Bennett, Jason W.

AU - Cybulski, Robert J.

AU - White, Brian K.

PY - 2021

Y1 - 2021

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AB - Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase blaNDM-1, the extended-spectrum β-lactamase blaPER-1, and the rare 16S methyltransferase rmtB2.

KW - COVID-19

KW - Cefiderocol resistance

KW - NDM carbapenemase

KW - Providencia rettgeri

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DO - 10.1099/jmm.0.001406

M3 - Article

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AN - SCOPUS:85114083678

SN - 0022-2615

VL - 70

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

IS - 8

M1 - 001406

ER -

Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Abstract

Keywords

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