Pancreas whole organ engineering

Catalina Pineda Molina; Yoojin C. Lee; Stephen F. Badylak

doi:10.1016/B978-0-12-814831-0.00038-5

Pancreas whole organ engineering

Catalina Pineda Molina, Yoojin C. Lee, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

Pancreatic failure as a result of inflammation or neoplasia is a life-threatening problem with limited therapeutic options. Pancreatic transplantation is limited by lack of donor availability, organ rejection, and the morbidity associated with lifelong immunosuppression. Whole organ pancreatic engineering offers a potential significant advancement in the treatment of pancreatic insufficiency. The fundamental building blocks of whole organ engineering include cell harvesting, development of biocompatible scaffold materials, and a favorable modulation of the host response, among others. This chapter reviews current and future regenerative medicine strategies for creating functional pancreatic tissue, and the remaining challenges of the whole organ engineering field.

Original language	English
Title of host publication	Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
Subtitle of host publication	Volume 2
Publisher	Elsevier
Pages	527-536
Number of pages	10
ISBN (Electronic)	9780128148310
ISBN (Print)	9780128148327
DOIs	https://doi.org/10.1016/B978-0-12-814831-0.00038-5
State	Published - 1 Jan 2019
Externally published	Yes

Keywords

Decellularization
Endocrine pancreas
Exocrine pancreas
Host response
Immunomodulation
Pancreatic tissue engineering
Recellularization
Whole organ engineering

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10.1016/B978-0-12-814831-0.00038-5

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title = "Pancreas whole organ engineering",

abstract = "Pancreatic failure as a result of inflammation or neoplasia is a life-threatening problem with limited therapeutic options. Pancreatic transplantation is limited by lack of donor availability, organ rejection, and the morbidity associated with lifelong immunosuppression. Whole organ pancreatic engineering offers a potential significant advancement in the treatment of pancreatic insufficiency. The fundamental building blocks of whole organ engineering include cell harvesting, development of biocompatible scaffold materials, and a favorable modulation of the host response, among others. This chapter reviews current and future regenerative medicine strategies for creating functional pancreatic tissue, and the remaining challenges of the whole organ engineering field.",

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T1 - Pancreas whole organ engineering

AU - Molina, Catalina Pineda

AU - Lee, Yoojin C.

AU - Badylak, Stephen F.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Pancreatic failure as a result of inflammation or neoplasia is a life-threatening problem with limited therapeutic options. Pancreatic transplantation is limited by lack of donor availability, organ rejection, and the morbidity associated with lifelong immunosuppression. Whole organ pancreatic engineering offers a potential significant advancement in the treatment of pancreatic insufficiency. The fundamental building blocks of whole organ engineering include cell harvesting, development of biocompatible scaffold materials, and a favorable modulation of the host response, among others. This chapter reviews current and future regenerative medicine strategies for creating functional pancreatic tissue, and the remaining challenges of the whole organ engineering field.

AB - Pancreatic failure as a result of inflammation or neoplasia is a life-threatening problem with limited therapeutic options. Pancreatic transplantation is limited by lack of donor availability, organ rejection, and the morbidity associated with lifelong immunosuppression. Whole organ pancreatic engineering offers a potential significant advancement in the treatment of pancreatic insufficiency. The fundamental building blocks of whole organ engineering include cell harvesting, development of biocompatible scaffold materials, and a favorable modulation of the host response, among others. This chapter reviews current and future regenerative medicine strategies for creating functional pancreatic tissue, and the remaining challenges of the whole organ engineering field.

KW - Decellularization

KW - Endocrine pancreas

KW - Exocrine pancreas

KW - Host response

KW - Immunomodulation

KW - Pancreatic tissue engineering

KW - Recellularization

KW - Whole organ engineering

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DO - 10.1016/B978-0-12-814831-0.00038-5

M3 - Chapter

AN - SCOPUS:85093491915

SN - 9780128148327

SP - 527

EP - 536

BT - Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas

PB - Elsevier

ER -

Pancreas whole organ engineering

Abstract

Keywords

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