Pancreas whole organ engineering

Catalina Pineda Molina, Yoojin C. Lee, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Pancreatic failure as a result of inflammation or neoplasia is a life-threatening problem with limited therapeutic options. Pancreatic transplantation is limited by lack of donor availability, organ rejection, and the morbidity associated with lifelong immunosuppression. Whole organ pancreatic engineering offers a potential significant advancement in the treatment of pancreatic insufficiency. The fundamental building blocks of whole organ engineering include cell harvesting, development of biocompatible scaffold materials, and a favorable modulation of the host response, among others. This chapter reviews current and future regenerative medicine strategies for creating functional pancreatic tissue, and the remaining challenges of the whole organ engineering field.

Original languageEnglish
Title of host publicationTransplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
Subtitle of host publicationVolume 2
Number of pages10
ISBN (Electronic)9780128148310
ISBN (Print)9780128148327
StatePublished - 1 Jan 2019
Externally publishedYes


  • Decellularization
  • Endocrine pancreas
  • Exocrine pancreas
  • Host response
  • Immunomodulation
  • Pancreatic tissue engineering
  • Recellularization
  • Whole organ engineering


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