TY - JOUR
T1 - Pathological τ proteins in postencephalitic Parkinsonism
T2 - Comparison with Alzheimer's disease and other neurodegenerative disorders
AU - Buée-Scherrer, Valérie
AU - Buée, Luc
AU - Leveugle, Béatrice
AU - Perl, Daniel P.
AU - Vermersch, Patrick
AU - Hof, Patrick R.
AU - Delacourte, André
PY - 1997/9
Y1 - 1997/9
N2 - Immunohistochemical and biochemical analyses of hyperphosphorylated τ proteins, the major component of neurofibrillary tangles, were performed in different brain regions from patients presenting with postencephalitic parkinsonism. Neurofibrillary tangles were found in hippocampus, neocortical areas (mostly in supragranular layers), and several subcortical structures. By immunoblotting, a τ protein triplet similar to the one seen in Alzheimer's disease was observed. This biochemical approach allows for the definition of postencephalitic parkinsonism from certain neurodegenerative disorders such as progressive supranuclear palsy and corticobasal degeneration.
AB - Immunohistochemical and biochemical analyses of hyperphosphorylated τ proteins, the major component of neurofibrillary tangles, were performed in different brain regions from patients presenting with postencephalitic parkinsonism. Neurofibrillary tangles were found in hippocampus, neocortical areas (mostly in supragranular layers), and several subcortical structures. By immunoblotting, a τ protein triplet similar to the one seen in Alzheimer's disease was observed. This biochemical approach allows for the definition of postencephalitic parkinsonism from certain neurodegenerative disorders such as progressive supranuclear palsy and corticobasal degeneration.
UR - http://www.scopus.com/inward/record.url?scp=0039707140&partnerID=8YFLogxK
U2 - 10.1002/ana.410420312
DO - 10.1002/ana.410420312
M3 - Article
C2 - 9307257
AN - SCOPUS:0039707140
SN - 0364-5134
VL - 42
SP - 356
EP - 359
JO - Annals of Neurology
JF - Annals of Neurology
IS - 3
ER -