Periodic re-emergence of endemic strains with strong epidemic potential-A proposed explanation for the 2004 Indonesian dengue epidemic

Swee Hoe Ong, Jin Teen Yip, Yen Liang Chen, Wei Liu, Syahrial Harun, Erlin Lystiyaningsih, Bambang Heriyanto, Charmagne G. Beckett, Wayne P. Mitchell, Martin L. Hibberd, Agus Suwandono, Subhash G. Vasudevan, Mark J. Schreiber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Indonesia experienced a severe dengue epidemic in the first quarter of 2004 with 58,301 cases and 658 deaths reported to the WHO. All four dengue virus (DENV) serotypes were detected, with DENV-3 the predominant strain. To ascertain the molecular epidemiology of the DENV associated with the epidemic, complete genomes of 15 isolates were sequenced from patient serum collected in Jakarta during the epidemic, and two historical DENV-3 isolates from previous epidemics in 1988 and 1998 were selectively sequenced for comparative studies. Phylogenetic trees for all four serotypes indicate the viruses are endemic strains that have been circulating in Indonesia for a few decades. Whole-genome phylogeny showed the 2004 DENV-3 isolates share high similarity with those isolated in 1998 during a major epidemic in Sumatra. Together these subtype I DENV-3 strains form a Sumatran-Javan clade with demonstrated epidemic potential. No newly-acquired amino acid mutations were found while comparing genomes from the two epidemics. This suggests re-emergence of little-changed endemic strains as causative agents of the epidemic in 2004. Notably, the molecular evidence rules out change in the viral genomes as the trigger of the epidemic.

Original languageEnglish
Pages (from-to)191-204
Number of pages14
JournalInfection, Genetics and Evolution
Volume8
Issue number2
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Dengue
  • Epidemic
  • Genome
  • Molecular epidemiology

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