Pharmacogenetics of membrane transporters: A review of current approaches

Tristan M. Sissung, Andrew K.L. Goey, Ariel M. Ley, Jonathan D. Strope, William D. Figg

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

This chapter provides a review of the pharmacogenetics of membrane transporters, including ABC transporters and OATPs. Membrane transporters are heavily involved in drug disposition, by actively transporting substrate drugs between organs and tissues. As such, polymorphisms in the genes encoding these proteins may have a signifi cant effect on the absorption, distribution, metabolism, excretion, and activity of compounds. Although few drug transporter polymorphisms have transitioned from the bench to the bedside, this chapter discusses clinical development of transporter pharmacogenetic markers. Finally, development of SLCO1B1 genotyping to avoid statin induced adverse drug reactions is discussed as a model case for transporter pharmacogenetics clinical development.

Original languageEnglish
Pages (from-to)91-120
Number of pages30
JournalMethods in molecular biology (Clifton, N.J.)
Volume1175
DOIs
StatePublished - 2014

Keywords

  • ABCB1
  • ABCC1
  • ABCC2
  • ABCG2
  • OATP1B1
  • OATP1B3
  • Polymorphisms
  • Transport

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