Pharmacogenomics of ABC transporters and its role in cancer chemotherapy

Alex Sparreboom; Romano Danesi; Yuichi Ando; Juliana Chan; William D. Figg

doi:10.1016/S1368-7646(03)00005-0

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy

Alex Sparreboom, Romano Danesi, Yuichi Ando, Juliana Chan, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

214 Scopus citations

Abstract

ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer.

Original language	English
Pages (from-to)	71-84
Number of pages	14
Journal	Drug Resistance Updates
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/S1368-7646(03)00005-0
State	Published - Apr 2003
Externally published	Yes

Keywords

ABC transporters
Chemotherapy
Pharmacogenetics
Polymorphisms

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10.1016/S1368-7646(03)00005-0

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title = "Pharmacogenomics of ABC transporters and its role in cancer chemotherapy",

abstract = "ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer.",

keywords = "ABC transporters, Chemotherapy, Pharmacogenetics, Polymorphisms",

author = "Alex Sparreboom and Romano Danesi and Yuichi Ando and Juliana Chan and Figg, {William D.}",

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TY - JOUR

T1 - Pharmacogenomics of ABC transporters and its role in cancer chemotherapy

AU - Sparreboom, Alex

AU - Danesi, Romano

AU - Ando, Yuichi

AU - Chan, Juliana

AU - Figg, William D.

PY - 2003/4

Y1 - 2003/4

N2 - ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer.

AB - ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer.

KW - ABC transporters

KW - Chemotherapy

KW - Pharmacogenetics

KW - Polymorphisms

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U2 - 10.1016/S1368-7646(03)00005-0

DO - 10.1016/S1368-7646(03)00005-0

M3 - Short survey

C2 - 12729805

AN - SCOPUS:0037988709

SN - 1368-7646

VL - 6

SP - 71

EP - 84

JO - Drug Resistance Updates

JF - Drug Resistance Updates

IS - 2

ER -

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy

Abstract

Keywords

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