Phase-variable expression of lptA modulates the resistance of neisseria gonorrhoeae to cationic antimicrobial peptides

Justin L. Kandler; Sandeep J. Joseph; Jacqueline T. Balthazar; Vijaya Dhulipala; Timothy D. Read; Ann E. Jerse; William M. Shafer

doi:10.1128/AAC.03108-14

Phase-variable expression of lptA modulates the resistance of neisseria gonorrhoeae to cationic antimicrobial peptides

Justin L. Kandler, Sandeep J. Joseph, Jacqueline T. Balthazar, Vijaya Dhulipala, Timothy D. Read, Ann E. Jerse, William M. Shafer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide repeat within lptA can influence gonococcal resistance to CAMPs.

Original language	English
Pages (from-to)	4230-4233
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	58
Issue number	7
DOIs	https://doi.org/10.1128/AAC.03108-14
State	Published - Jul 2014
Externally published	Yes

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10.1128/AAC.03108-14

Cite this

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abstract = "Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide repeat within lptA can influence gonococcal resistance to CAMPs.",

author = "Kandler, {Justin L.} and Joseph, {Sandeep J.} and Balthazar, {Jacqueline T.} and Vijaya Dhulipala and Read, {Timothy D.} and Jerse, {Ann E.} and Shafer, {William M.}",

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AU - Joseph, Sandeep J.

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AU - Dhulipala, Vijaya

AU - Read, Timothy D.

AU - Jerse, Ann E.

AU - Shafer, William M.

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AB - Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide repeat within lptA can influence gonococcal resistance to CAMPs.

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