Phenotypic and genomic analysis of bacteria from war wounds in Dnipro, Ukraine

Dmytro Stepanskyi; Oksana Ishchenko; Ting Luo; Francois Lebreton; Jason W. Bennett; Iryna Kovalenko; Patrick McGann

doi:10.1093/jacamr/dlae090

Phenotypic and genomic analysis of bacteria from war wounds in Dnipro, Ukraine

Dmytro Stepanskyi^*, Oksana Ishchenko, Ting Luo, Francois Lebreton, Jason W. Bennett, Iryna Kovalenko, Patrick McGann

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objectives: To better understand the source and potential transmission routes of antibiotic-resistant bacteria infecting injured service members in Ukraine. Methods: Phenotypic and genomic characterizations were performed on 11 Gram-negative pathogens cultured from war wounds at an intermediate evacuation hospital in Dnipro. Results: The analysis revealed both susceptible and extensively drug-resistant strains present in cultures, including high-risk global clones carrying carbapenemases. Conclusions: Globally distributed carbapenemase-producing lineages are being acquired early in the medical evacuation process.

Original language	English
Article number	dlae090
Journal	JAC-Antimicrobial Resistance
Volume	6
Issue number	3
DOIs	https://doi.org/10.1093/jacamr/dlae090
State	Published - 1 Jun 2024
Externally published	Yes

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title = "Phenotypic and genomic analysis of bacteria from war wounds in Dnipro, Ukraine",

abstract = "Objectives: To better understand the source and potential transmission routes of antibiotic-resistant bacteria infecting injured service members in Ukraine. Methods: Phenotypic and genomic characterizations were performed on 11 Gram-negative pathogens cultured from war wounds at an intermediate evacuation hospital in Dnipro. Results: The analysis revealed both susceptible and extensively drug-resistant strains present in cultures, including high-risk global clones carrying carbapenemases. Conclusions: Globally distributed carbapenemase-producing lineages are being acquired early in the medical evacuation process.",

author = "Dmytro Stepanskyi and Oksana Ishchenko and Ting Luo and Francois Lebreton and Bennett, {Jason W.} and Iryna Kovalenko and Patrick McGann",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.",

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AU - Stepanskyi, Dmytro

AU - Ishchenko, Oksana

AU - Luo, Ting

AU - Lebreton, Francois

AU - Bennett, Jason W.

AU - Kovalenko, Iryna

AU - McGann, Patrick

PY - 2024/6/1

Y1 - 2024/6/1

N2 - Objectives: To better understand the source and potential transmission routes of antibiotic-resistant bacteria infecting injured service members in Ukraine. Methods: Phenotypic and genomic characterizations were performed on 11 Gram-negative pathogens cultured from war wounds at an intermediate evacuation hospital in Dnipro. Results: The analysis revealed both susceptible and extensively drug-resistant strains present in cultures, including high-risk global clones carrying carbapenemases. Conclusions: Globally distributed carbapenemase-producing lineages are being acquired early in the medical evacuation process.

AB - Objectives: To better understand the source and potential transmission routes of antibiotic-resistant bacteria infecting injured service members in Ukraine. Methods: Phenotypic and genomic characterizations were performed on 11 Gram-negative pathogens cultured from war wounds at an intermediate evacuation hospital in Dnipro. Results: The analysis revealed both susceptible and extensively drug-resistant strains present in cultures, including high-risk global clones carrying carbapenemases. Conclusions: Globally distributed carbapenemase-producing lineages are being acquired early in the medical evacuation process.

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JO - JAC-Antimicrobial Resistance

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Phenotypic and genomic analysis of bacteria from war wounds in Dnipro, Ukraine

Abstract

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