Phosphoinositide turnover in human platelets is stimulated by albumin

Riyad M. Amin, James H. Hays, K. M. Mohamed Shakir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The effect of human serum albumin (HSA) on the hydrolysis of phosphatidylinositides in human platelets labeled with myo(3H)inositol was studied. Incubation of platelets with HSA (4 gm/dl) for 10 seconds increased IP2 and IP3 by 169% and 217% respectively. 93% of IP3 accumulated within the first 10 seconds. This effect was also shared by bovine serum albumin, although no changes in IP3 levels occured with ovalbumin. All albumin species used induced 45Ca+2 release from platelets irrespective of its effect on IP3 accumulation. These findings indicate that albumin may function in biological systems by inducing intracellular signaling.

Original languageEnglish
Pages (from-to)1707-1719
Number of pages13
JournalLife Sciences
Issue number23
StatePublished - 1991
Externally publishedYes


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