TY - JOUR
T1 - Phylogeography of influenza A(H3N2) virus in Peru, 2010–2012
AU - Pollett, Simon
AU - Nelson, Martha I.
AU - Kasper, Matthew
AU - Tinoco, Yeny
AU - Simons, Mark
AU - Romero, Candice
AU - Silva, Marita
AU - Lin, Xudong
AU - Halpin, Rebecca A.
AU - Fedorova, Nadia
AU - Stockwell, Timothy B.
AU - Wentworth, David
AU - Holmes, Edward C.
AU - Bausch, Daniel G.
N1 - Publisher Copyright:
© 2015, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2015/7/23
Y1 - 2015/7/23
N2 - It remains unclear whether lineages of influenza A(H3N2) virus can persist in the tropics and seed temperate areas. We used viral gene sequence data sampled from Peru to test this source–sink model for a Latin American country. Viruses were obtained during 2010–2012 from influenza surveillance cohorts in Cusco, Tumbes, Puerto Maldonado, and Lima. Specimens positive for influenza A(H3N2) virus were randomly selected and underwent hemagglutinin sequencing and phylogeographic analyses. Analysis of 389 hemagglutinin sequences from Peru and 2,192 global sequences demonstrated interseasonal extinction of Peruvian lineages. Extensive mixing occurred with global clades, but some spatial structure was observed at all sites; this structure was weakest in Lima and Puerto Maldonado, indicating that these locations may experience greater viral traffic. The broad diversity and co-circulation of many simultaneous lineages of H3N2 virus in Peru suggests that this country should not be overlooked as a potential source for novel pandemic strains.
AB - It remains unclear whether lineages of influenza A(H3N2) virus can persist in the tropics and seed temperate areas. We used viral gene sequence data sampled from Peru to test this source–sink model for a Latin American country. Viruses were obtained during 2010–2012 from influenza surveillance cohorts in Cusco, Tumbes, Puerto Maldonado, and Lima. Specimens positive for influenza A(H3N2) virus were randomly selected and underwent hemagglutinin sequencing and phylogeographic analyses. Analysis of 389 hemagglutinin sequences from Peru and 2,192 global sequences demonstrated interseasonal extinction of Peruvian lineages. Extensive mixing occurred with global clades, but some spatial structure was observed at all sites; this structure was weakest in Lima and Puerto Maldonado, indicating that these locations may experience greater viral traffic. The broad diversity and co-circulation of many simultaneous lineages of H3N2 virus in Peru suggests that this country should not be overlooked as a potential source for novel pandemic strains.
UR - http://www.scopus.com/inward/record.url?scp=84937394367&partnerID=8YFLogxK
U2 - 10.3201/eid2108.150084
DO - 10.3201/eid2108.150084
M3 - Article
C2 - 26196599
AN - SCOPUS:84937394367
SN - 1080-6040
VL - 21
SP - 1330
EP - 1338
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 8
ER -