TY - JOUR
T1 - Physiologic stability and physiologic state
AU - Buchman, Timothy G.
PY - 1996/10
Y1 - 1996/10
N2 - Several disease states (e.g., disseminated inflammation) demonstrate physiologic stability: they resolve only slowly and are resistant to both specific and symptomatic therapies. The existence of multiple stable physiologic states, including both health and disease states, is not anticipated by classical, linear descriptions of physiologic control mechanisms. Multiple stable states are, however, predicted by a simple nonlinear model in which the resistance to perturbation derives from interconnections among the model's elements. If the stability of selected disease states derives from nonlinear interactions among cells, tissues, and organs, then some therapies aimed at supporting or normalizing performance of specific organs may be misdirected.
AB - Several disease states (e.g., disseminated inflammation) demonstrate physiologic stability: they resolve only slowly and are resistant to both specific and symptomatic therapies. The existence of multiple stable physiologic states, including both health and disease states, is not anticipated by classical, linear descriptions of physiologic control mechanisms. Multiple stable states are, however, predicted by a simple nonlinear model in which the resistance to perturbation derives from interconnections among the model's elements. If the stability of selected disease states derives from nonlinear interactions among cells, tissues, and organs, then some therapies aimed at supporting or normalizing performance of specific organs may be misdirected.
UR - http://www.scopus.com/inward/record.url?scp=0029858597&partnerID=8YFLogxK
U2 - 10.1097/00005373-199610000-00002
DO - 10.1097/00005373-199610000-00002
M3 - Article
C2 - 8858016
AN - SCOPUS:0029858597
SN - 0022-5282
VL - 41
SP - 599
EP - 605
JO - Journal of Trauma - Injury, Infection and Critical Care
JF - Journal of Trauma - Injury, Infection and Critical Care
IS - 4
ER -