Physiological evaluation of a rabbit kidney perfused with VS41A

Françoise G. Arnaud, Bijan Khirabadi, Gregory M. Fahy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalCryobiology
Volume46
Issue number3
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Cryopreservation
  • Dimethyl sulfoxide
  • Formamide
  • Isolated perfused kidney
  • Machine-perfused kidney
  • Propylene glycol
  • VS55

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