TY - JOUR
T1 - Physiological evaluation of a rabbit kidney perfused with VS41A
AU - Arnaud, Françoise G.
AU - Khirabadi, Bijan
AU - Fahy, Gregory M.
N1 - Funding Information:
This work was supported by Work Unit Number (WUN) No. 61153N4120.0011462.
PY - 2003/6
Y1 - 2003/6
N2 - The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.
AB - The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.
KW - Cryopreservation
KW - Dimethyl sulfoxide
KW - Formamide
KW - Isolated perfused kidney
KW - Machine-perfused kidney
KW - Propylene glycol
KW - VS55
UR - http://www.scopus.com/inward/record.url?scp=0038348298&partnerID=8YFLogxK
U2 - 10.1016/S0011-2240(03)00045-2
DO - 10.1016/S0011-2240(03)00045-2
M3 - Article
C2 - 12818220
AN - SCOPUS:0038348298
SN - 0011-2240
VL - 46
SP - 289
EP - 294
JO - Cryobiology
JF - Cryobiology
IS - 3
ER -