Physiological evaluation of a rabbit kidney perfused with VS41A

Françoise G. Arnaud; Bijan Khirabadi; Gregory M. Fahy

doi:10.1016/S0011-2240(03)00045-2

Physiological evaluation of a rabbit kidney perfused with VS41A

Françoise G. Arnaud, Bijan Khirabadi, Gregory M. Fahy^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.

Original language	English
Pages (from-to)	289-294
Number of pages	6
Journal	Cryobiology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/S0011-2240(03)00045-2
State	Published - Jun 2003
Externally published	Yes

Keywords

Cryopreservation
Dimethyl sulfoxide
Formamide
Isolated perfused kidney
Machine-perfused kidney
Propylene glycol
VS55

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10.1016/S0011-2240(03)00045-2

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title = "Physiological evaluation of a rabbit kidney perfused with VS41A",

abstract = "The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.",

keywords = "Cryopreservation, Dimethyl sulfoxide, Formamide, Isolated perfused kidney, Machine-perfused kidney, Propylene glycol, VS55",

author = "Arnaud, {Fran{\c c}oise G.} and Bijan Khirabadi and Fahy, {Gregory M.}",

note = "Funding Information: This work was supported by Work Unit Number (WUN) No. 61153N4120.0011462. ",

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AU - Arnaud, Françoise G.

AU - Khirabadi, Bijan

AU - Fahy, Gregory M.

N1 - Funding Information: This work was supported by Work Unit Number (WUN) No. 61153N4120.0011462.

PY - 2003/6

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N2 - The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.

AB - The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.

KW - Cryopreservation

KW - Dimethyl sulfoxide

KW - Formamide

KW - Isolated perfused kidney

KW - Machine-perfused kidney

KW - Propylene glycol

KW - VS55

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SN - 0011-2240

VL - 46

SP - 289

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JO - Cryobiology

JF - Cryobiology

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ER -

Physiological evaluation of a rabbit kidney perfused with VS41A

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Keywords

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