TY - JOUR
T1 - Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis
AU - Chung, Michael T.
AU - Levi, Benjamin
AU - Hyun, Jeong S.
AU - Lo, David D.
AU - Montoro, Daniel T.
AU - Lisiecki, Jeffrey
AU - Bradley, James P.
AU - Buchman, Steven R.
AU - Longaker, Michael T.
AU - Wan, Derrick C.
PY - 2012/11
Y1 - 2012/11
N2 - Pierre Robin sequence and Treacher Collins syndrome are both associated with mandibular hypoplasia. It has been hypothesized, however, that the mandible may be differentially affected. The purpose of this study was to therefore compare mandibular morphology in children with Pierre Robin sequence with children with Treacher Collins syndrome using three-dimensional analysis of computed tomographic scans. A retrospective analysis was performed identifying children with Pierre Robin sequence and Treacher Collins syndrome undergoing computed tomography. Three-dimensional reconstruction was performed, and ramus height, mandibular body length, and gonial angle were measured. These were then compared with those in control children with normal mandibles and with the clinical norms corrected for age and sex based on previously published measurements. Mandibular body length was found to be significantly shorter for children with Pierre Robin sequence, whereas ramus height was significantly shorter for children with Treacher Collins syndrome. This resulted in distinctly different ramus height-mandibular body length ratios. In addition, the gonial angle was more obtuse in both the Pierre Robin sequence and Treacher Collins syndrome groups compared with the controls. Three-dimensional mandibular morphometric analysis in patients with Pierre Robin sequence and Treacher Collins syndrome thus revealed distinctly different patterns of mandibular hypoplasiarelative to normal controls. These findings underscore distinct considerations that must be made in surgical planning for reconstruction.
AB - Pierre Robin sequence and Treacher Collins syndrome are both associated with mandibular hypoplasia. It has been hypothesized, however, that the mandible may be differentially affected. The purpose of this study was to therefore compare mandibular morphology in children with Pierre Robin sequence with children with Treacher Collins syndrome using three-dimensional analysis of computed tomographic scans. A retrospective analysis was performed identifying children with Pierre Robin sequence and Treacher Collins syndrome undergoing computed tomography. Three-dimensional reconstruction was performed, and ramus height, mandibular body length, and gonial angle were measured. These were then compared with those in control children with normal mandibles and with the clinical norms corrected for age and sex based on previously published measurements. Mandibular body length was found to be significantly shorter for children with Pierre Robin sequence, whereas ramus height was significantly shorter for children with Treacher Collins syndrome. This resulted in distinctly different ramus height-mandibular body length ratios. In addition, the gonial angle was more obtuse in both the Pierre Robin sequence and Treacher Collins syndrome groups compared with the controls. Three-dimensional mandibular morphometric analysis in patients with Pierre Robin sequence and Treacher Collins syndrome thus revealed distinctly different patterns of mandibular hypoplasiarelative to normal controls. These findings underscore distinct considerations that must be made in surgical planning for reconstruction.
KW - Computed tomography
KW - Pierre Robin sequence
KW - Treacher Collins syndrome
KW - mandibular hypoplasia
KW - morphometric analysis
UR - http://www.scopus.com/inward/record.url?scp=84870168651&partnerID=8YFLogxK
U2 - 10.1097/SCS.0b013e318258bcf1
DO - 10.1097/SCS.0b013e318258bcf1
M3 - Article
C2 - 23154353
AN - SCOPUS:84870168651
SN - 1049-2275
VL - 23
SP - S17-S21
JO - Journal of Craniofacial Surgery
JF - Journal of Craniofacial Surgery
IS - 7 SUPPL.1
ER -