TY - JOUR
T1 - Placental Exosomes as Biomarkers for Maternal Diseases
T2 - Current Advances in Isolation, Characterization, and Detection
AU - Nguyen, Cong Minh
AU - Sallam, Mohamed
AU - Islam, Md Sajedul
AU - Clack, Kimberley
AU - Soda, Narshone
AU - Nguyen, Nam Trung
AU - Shiddiky, Muhammad J.A.
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/7/28
Y1 - 2023/7/28
N2 - Serving as the interface between fetal and maternal circulation, the placenta plays a critical role in fetal growth and development. Placental exosomes are small membrane-bound extracellular vesicles released by the placenta during pregnancy. They contain a variety of biomolecules, including lipids, proteins, and nucleic acids, which can potentially be biomarkers of maternal diseases. An increasing number of studies have demonstrated the utility of placental exosomes for the diagnosis and monitoring of pathological conditions such as pre-eclampsia and gestational diabetes. This suggests that placental exosomes may serve as new biomarkers in liquid biopsy analysis. This review provides an overview of the current understanding of the biological function of placental exosomes and their potential as biomarkers of maternal diseases. Additionally, this review highlights current barriers and the way forward for standardization and validation of known techniques for exosome isolation, characterization, and detection. Finally, microfluidic devices for exosome research are discussed.
AB - Serving as the interface between fetal and maternal circulation, the placenta plays a critical role in fetal growth and development. Placental exosomes are small membrane-bound extracellular vesicles released by the placenta during pregnancy. They contain a variety of biomolecules, including lipids, proteins, and nucleic acids, which can potentially be biomarkers of maternal diseases. An increasing number of studies have demonstrated the utility of placental exosomes for the diagnosis and monitoring of pathological conditions such as pre-eclampsia and gestational diabetes. This suggests that placental exosomes may serve as new biomarkers in liquid biopsy analysis. This review provides an overview of the current understanding of the biological function of placental exosomes and their potential as biomarkers of maternal diseases. Additionally, this review highlights current barriers and the way forward for standardization and validation of known techniques for exosome isolation, characterization, and detection. Finally, microfluidic devices for exosome research are discussed.
KW - biomarker
KW - exosome isolation and characterization
KW - liquid biopsy
KW - maternal disease
KW - placental exosome
KW - syncytiotrophoblast extracellular vesicles
UR - http://www.scopus.com/inward/record.url?scp=85165910090&partnerID=8YFLogxK
U2 - 10.1021/acssensors.3c00689
DO - 10.1021/acssensors.3c00689
M3 - Review article
C2 - 37449399
AN - SCOPUS:85165910090
SN - 2379-3694
VL - 8
SP - 2493
EP - 2513
JO - ACS Sensors
JF - ACS Sensors
IS - 7
ER -