Plasmodium development in the mosquito: biology bottlenecks and opportunities for mathematical modeling

Anna L. Drexler*, Yoram Vodovotz, Shirley Luckhart

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations

Abstract

Quantitative analyses of malaria parasite development are necessary to assess the efficacy of control measures. Such analyses in the mammalian host have been difficult to implement, lagging behind the use of antiparasitic drugs, vaccine development and transmission-blocking strategies. Even less is known about the genetic, environmental and other factors that impact sporogony in the mosquito host. Here, we summarize current knowledge and review a first attempt to model sporogonic development quantitatively.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalTrends in Parasitology
Volume24
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

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