TY - JOUR
T1 - Plasmodium development in the mosquito
T2 - biology bottlenecks and opportunities for mathematical modeling
AU - Drexler, Anna L.
AU - Vodovotz, Yoram
AU - Luckhart, Shirley
N1 - Funding Information:
S.L. and A.L.D. are supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID) (AI50663, AI60664) and the National Center for Research Resources (Research Facilities Improvement Grant C06 RR-12088–01). Y.V. is supported by NIAID grant AI50663 and the National Institute of General Medical Sciences grant P50-GM-53789.
PY - 2008/8
Y1 - 2008/8
N2 - Quantitative analyses of malaria parasite development are necessary to assess the efficacy of control measures. Such analyses in the mammalian host have been difficult to implement, lagging behind the use of antiparasitic drugs, vaccine development and transmission-blocking strategies. Even less is known about the genetic, environmental and other factors that impact sporogony in the mosquito host. Here, we summarize current knowledge and review a first attempt to model sporogonic development quantitatively.
AB - Quantitative analyses of malaria parasite development are necessary to assess the efficacy of control measures. Such analyses in the mammalian host have been difficult to implement, lagging behind the use of antiparasitic drugs, vaccine development and transmission-blocking strategies. Even less is known about the genetic, environmental and other factors that impact sporogony in the mosquito host. Here, we summarize current knowledge and review a first attempt to model sporogonic development quantitatively.
UR - http://www.scopus.com/inward/record.url?scp=47649116758&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2008.05.005
DO - 10.1016/j.pt.2008.05.005
M3 - Short survey
C2 - 18603475
AN - SCOPUS:47649116758
SN - 1471-4922
VL - 24
SP - 333
EP - 336
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 8
ER -