Platelet and red cell responses to three North American pit vipers

Samuel Francis; Sanjay Khandelwal; Richard Straight; Luke Welton; Pengfei Liang; Huanghe Yang; Charles J. Gerardo; Gowthami Arepally

doi:10.1016/j.toxicon.2024.107798

Platelet and red cell responses to three North American pit vipers

Samuel Francis^*, Sanjay Khandelwal, Richard Straight, Luke Welton, Pengfei Liang, Huanghe Yang, Charles J. Gerardo, Gowthami Arepally

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the hemotoxic effects of three North American pit vipers in healthy human donor blood. Using experiments focusing on platelet and red blood cell activity, we found differential effects of these venoms on these cellular components. Platelet aggregation was most induced by C. adamanteus. Platelet activation was highest with C. atrox. Red blood cells had calcium expression and erythrocyte formation most induced by C. adamanteus and A. piscivorus. These results demonstrate the complex interplay of individual cellular effects with clinical presentations seen in envenomings from these species.

Original language	English
Article number	107798
Journal	Toxicon
Volume	247
DOIs	https://doi.org/10.1016/j.toxicon.2024.107798
State	Published - 28 Aug 2024
Externally published	Yes

Access to Document

10.1016/j.toxicon.2024.107798

Cite this

@article{e9d0383ab37a4a5fad7c3bb90c02773c,

title = "Platelet and red cell responses to three North American pit vipers",

abstract = "We investigated the hemotoxic effects of three North American pit vipers in healthy human donor blood. Using experiments focusing on platelet and red blood cell activity, we found differential effects of these venoms on these cellular components. Platelet aggregation was most induced by C. adamanteus. Platelet activation was highest with C. atrox. Red blood cells had calcium expression and erythrocyte formation most induced by C. adamanteus and A. piscivorus. These results demonstrate the complex interplay of individual cellular effects with clinical presentations seen in envenomings from these species.",

author = "Samuel Francis and Sanjay Khandelwal and Richard Straight and Luke Welton and Pengfei Liang and Huanghe Yang and Gerardo, {Charles J.} and Gowthami Arepally",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = aug,

day = "28",

doi = "10.1016/j.toxicon.2024.107798",

language = "English",

volume = "247",

journal = "Toxicon",

issn = "0041-0101",

}

TY - JOUR

T1 - Platelet and red cell responses to three North American pit vipers

AU - Francis, Samuel

AU - Khandelwal, Sanjay

AU - Straight, Richard

AU - Welton, Luke

AU - Liang, Pengfei

AU - Yang, Huanghe

AU - Gerardo, Charles J.

AU - Arepally, Gowthami

PY - 2024/8/28

Y1 - 2024/8/28

N2 - We investigated the hemotoxic effects of three North American pit vipers in healthy human donor blood. Using experiments focusing on platelet and red blood cell activity, we found differential effects of these venoms on these cellular components. Platelet aggregation was most induced by C. adamanteus. Platelet activation was highest with C. atrox. Red blood cells had calcium expression and erythrocyte formation most induced by C. adamanteus and A. piscivorus. These results demonstrate the complex interplay of individual cellular effects with clinical presentations seen in envenomings from these species.

AB - We investigated the hemotoxic effects of three North American pit vipers in healthy human donor blood. Using experiments focusing on platelet and red blood cell activity, we found differential effects of these venoms on these cellular components. Platelet aggregation was most induced by C. adamanteus. Platelet activation was highest with C. atrox. Red blood cells had calcium expression and erythrocyte formation most induced by C. adamanteus and A. piscivorus. These results demonstrate the complex interplay of individual cellular effects with clinical presentations seen in envenomings from these species.

UR - http://www.scopus.com/inward/record.url?scp=85196617232&partnerID=8YFLogxK

U2 - 10.1016/j.toxicon.2024.107798

DO - 10.1016/j.toxicon.2024.107798

M3 - Article

C2 - 38871030

AN - SCOPUS:85196617232

SN - 0041-0101

VL - 247

JO - Toxicon

JF - Toxicon

M1 - 107798

ER -

Platelet and red cell responses to three North American pit vipers

Abstract

Access to Document

Fingerprint

Cite this