Platelet biomechanics, platelet bioenergetics, and applications to clinical practice and translational research

Mitchell J. George*, James Bynum, Prajeeda Nair, Andrew P. Cap, Charles E. Wade, Charles S. Cox, Brijesh S. Gill

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

The purpose of this review is to explore the relationship between platelet bioenergetics and biomechanics and how this relationship affects the clinical interpretation of platelet function devices. Recent experimental and technological advances highlight platelet bioenergetics and biomechanics as alternative avenues for collecting clinically relevant data. Platelet bioenergetics drive energy production for key biomechanical processes like adhesion, spreading, aggregation, and contraction. Platelet function devices like thromboelastography, thromboelastometry, and aggregometry measure these biomechanical processes. Platelet storage, stroke, sepsis, trauma, or the activity of antiplatelet drugs alters measures of platelet function. However, the specific mechanisms governing these alterations in platelet function and how they relate to platelet bioenergetics are still under investigation.

Original languageEnglish
Pages (from-to)431-439
Number of pages9
JournalPlatelets
Volume29
Issue number5
DOIs
StatePublished - 4 Jul 2018
Externally publishedYes

Keywords

  • Platelet bioenergetics and biomechanics

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