Platelet Transfusion

Andrew P. Cap; Todd M. Getz; Philip C. Spinella; Heather F. Pidcoke

doi:10.1007/978-3-319-28308-1_22

Platelet Transfusion

Andrew P. Cap^*, Todd M. Getz, Philip C. Spinella, Heather F. Pidcoke

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires an immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that supports the inadequate status quo. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in surgical care.

Original language	English
Title of host publication	Trauma Induced Coagulopathy
Publisher	Springer International Publishing
Pages	347-376
Number of pages	30
ISBN (Electronic)	9783319283081
ISBN (Print)	9783319283067
DOIs	https://doi.org/10.1007/978-3-319-28308-1_22
State	Published - 1 Jan 2016
Externally published	Yes

Keywords

Blood banking
Hemostasis
Platelet function
Platelet transfusion
Storage lesion
Trauma
Trauma-induced coagulopathy
Whole blood

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10.1007/978-3-319-28308-1_22

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title = "Platelet Transfusion",

abstract = "Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires an immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that supports the inadequate status quo. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in surgical care.",

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AU - Getz, Todd M.

AU - Spinella, Philip C.

AU - Pidcoke, Heather F.

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KW - Storage lesion

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KW - Trauma-induced coagulopathy

KW - Whole blood

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Platelet Transfusion

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