Platelet Transfusion

Andrew P. Cap*, Todd M. Getz, Philip C. Spinella, Heather F. Pidcoke

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires an immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that supports the inadequate status quo. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in surgical care.

Original languageEnglish
Title of host publicationTrauma Induced Coagulopathy
PublisherSpringer International Publishing
Number of pages30
ISBN (Electronic)9783319283081
ISBN (Print)9783319283067
StatePublished - 1 Jan 2016
Externally publishedYes


  • Blood banking
  • Hemostasis
  • Platelet function
  • Platelet transfusion
  • Storage lesion
  • Trauma
  • Trauma-induced coagulopathy
  • Whole blood


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