Platelet transfusion

Michael Adam Meledeo; Kimberly A. Thomas; James A. Bynum; Kristin M. Reddoch-Cardenas; Todd M. Getz; Heather F. Pidcoke; Philip C. Spinella; Andrew P. Cap

doi:10.1007/978-3-030-53606-0_23

Platelet transfusion

Michael Adam Meledeo, Kimberly A. Thomas, James A. Bynum, Kristin M. Reddoch-Cardenas, Todd M. Getz, Heather F. Pidcoke, Philip C. Spinella, Andrew P. Cap^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that does not facilitate optimizing platelet function. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in the care of bleeding patients or those at high risk of bleeding.

Original language	English
Title of host publication	Trauma Induced Coagulopathy
Publisher	Springer
Pages	391-428
Number of pages	38
ISBN (Electronic)	9783030536060
ISBN (Print)	9783030536053
DOIs	https://doi.org/10.1007/978-3-030-53606-0_23
State	Published - 12 Oct 2020
Externally published	Yes

Keywords

Blood banking
Hemostasis
Platelet function
Platelet transfusion
Storage lesion
Trauma
Trauma-induced coagulopathy
Whole blood

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10.1007/978-3-030-53606-0_23

Cite this

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abstract = "Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that does not facilitate optimizing platelet function. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in the care of bleeding patients or those at high risk of bleeding.",

keywords = "Blood banking, Hemostasis, Platelet function, Platelet transfusion, Storage lesion, Trauma, Trauma-induced coagulopathy, Whole blood",

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AU - Meledeo, Michael Adam

AU - Thomas, Kimberly A.

AU - Bynum, James A.

AU - Reddoch-Cardenas, Kristin M.

AU - Getz, Todd M.

AU - Pidcoke, Heather F.

AU - Spinella, Philip C.

AU - Cap, Andrew P.

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AB - Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that does not facilitate optimizing platelet function. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in the care of bleeding patients or those at high risk of bleeding.

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KW - Hemostasis

KW - Platelet function

KW - Platelet transfusion

KW - Storage lesion

KW - Trauma

KW - Trauma-induced coagulopathy

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Platelet transfusion

Abstract

Keywords

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