TY - JOUR
T1 - Platelets deliver costimulatory signals to antigen-presenting cells
T2 - A potential bridge between injury and immune activation
AU - Czapiga, Meggan
AU - Kirk, Allan D.
AU - Lekstrom-Himes, Julie
PY - 2004/2
Y1 - 2004/2
N2 - The danger model of immunity and tolerance holds that antigen-presenting cells (APCs), activated by stress, injury, or necrosis, but not by physiological (apoptotic) cell death, initiate adaptive immune responses. APC activation is fundamentally associated with binding of CD40 to its ligand CD154. Platelets express CD154 upon activation and are thus potential primal danger signals linking the homeostatic response to trauma to activation of the acquired immune system. Previously, we showed that platelets can undergo gradient-driven migration, or chemotaxis, toward supernatants from cells injured by repeated freeze/thaws, UV light, or ischemia/reperfusion. Herein, we demonstrate that platelet-derived CD154 induces immature dendritic cell maturation with upregulation of costimulatory molecules and IL-12p40 production. Overall, these results provide a mechanism for platelet activation of APC facilitating the induction of adaptive immunity in environments of cell injury.
AB - The danger model of immunity and tolerance holds that antigen-presenting cells (APCs), activated by stress, injury, or necrosis, but not by physiological (apoptotic) cell death, initiate adaptive immune responses. APC activation is fundamentally associated with binding of CD40 to its ligand CD154. Platelets express CD154 upon activation and are thus potential primal danger signals linking the homeostatic response to trauma to activation of the acquired immune system. Previously, we showed that platelets can undergo gradient-driven migration, or chemotaxis, toward supernatants from cells injured by repeated freeze/thaws, UV light, or ischemia/reperfusion. Herein, we demonstrate that platelet-derived CD154 induces immature dendritic cell maturation with upregulation of costimulatory molecules and IL-12p40 production. Overall, these results provide a mechanism for platelet activation of APC facilitating the induction of adaptive immunity in environments of cell injury.
UR - http://www.scopus.com/inward/record.url?scp=0842265837&partnerID=8YFLogxK
U2 - 10.1016/j.exphem.2003.11.004
DO - 10.1016/j.exphem.2003.11.004
M3 - Article
C2 - 15102473
AN - SCOPUS:0842265837
SN - 0301-472X
VL - 32
SP - 135
EP - 139
JO - Experimental Hematology
JF - Experimental Hematology
IS - 2
ER -