Pleural Space Infections

Sean P.F. Foley*, John Scott Parrish

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Pleural space infections have been a well-recognized clinical syndrome for over 4000 years and continue to cause significant morbidity and mortality worldwide. However, our collective understanding of the causative pathophysiology has greatly expanded over the last few decades, as have our treatment options. The aim of this paper is to review recent updates in our understanding of this troublesome disease and to provide updates on established and emerging treatment modalities for patients suffering from pleural space infections. With that, we present a review and discussion synthesizing the recent pertinent literature surrounding the history, epidemiology, pathophysiology, diagnosis, and management of these challenging infections.

Original languageEnglish
Article number376
Issue number2
StatePublished - Feb 2023
Externally publishedYes


  • empyema
  • interventional pulmonology
  • parapneumonic effusion
  • pleural disease
  • pleural effusion
  • pleural infections
  • pleural sepsis
  • pneumonia
  • pulmonary infections
  • unilateral pleural effusion


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